365441-86-7

Upstream product

• 4248-19-5 tert-butyl carbazate 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 2043-61-0 cyclohexanecarbaldehyde 

Downstream Products

• 1011258-58-4 diethyl [2-tert-butoxycarbonylamino-2-cyclohexyl-1-(diethoxyphosphoryl)ethyl]phosphonate 
• 1078719-40-0 (R)-tert-butyl cyclohexyl(dimethoxyphosphoryl)methylcarbamate 
• 1415650-26-8 (2,2-diiodo-1-phenyl-ethyl)-tert-butylcarbamate 
• 1389318-46-0 tert-butyl (2-chloro-6-methoxy-9H-purin-9-yl)(cyclohexyl)methylcarbamate 
• 1389318-41-5 tert-butylcyclohexyl(2,6-dichloro-9H-purin-9-yl)methyl-carbamate 
• 1389318-44-8 tert-butyl (2-amino-6-chloro-9H-purin-9-yl)(cyclohexyl)methylcarbamate 
• 1389318-43-7 tert-butyl (6-chloro-9H-purin-9-yl)(cyclohexyl)methylcarbamate 
• 1389318-45-9 tert-butyl (2-chloro-9H-purin-9-yl)(cyclohexyl)methylcarbamate 
• 1389318-47-1 tert-butyl (4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)(cyclohexyl)methylcarbamate 
• 1389318-42-6 tert-butyl cyclohexyl(9H-purin-9-yl)methylcarbamate 
• 1389318-61-9 tert-butyl (1H-benzo[d][1,2,3]triazol-1-yl)(cyclohexyl)methylcarbamate 
• 1389318-60-8 tert-butyl (1H-benzo[d]imidazol-1-yl)(cyclohexyl)methylcarbamate 
• 1389318-59-5 tert-butyl cyclohexyl(1H-imidazol-1-yl)methylcarbamate 
• 100049-94-3 ethyl 3-amino-3-cyclohexylpropanoate hydrochloride 

Relevant academic research and scientific papers

METTL3 INHIBITORY COMPOUNDS

The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X-Y-Z5 (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity 10 is implicated.

Highly cis-selective synthesis of iodo-aziridines using diiodomethyllithium and in situ generated N-Boc-imines

The first preparation of iodoaziridines is described. The addition of diiodomethyllithium to N-Boc-imines affords these novel aziridines in high yields. The reaction proceeds in one-pot via a highly diastereoselective cyclisation of an amino gem-diiodide

Reductive BOC-amination of aldehydes

Base-assisted elimination-reduction of α-amidoalkyl sulfones with sodium borohydride proceeds in tetrahydrofuran at room temperature leading to the corresponding BOC-amines in good yields.