365441-86-7

Basic information

• Product Name: Carbamic acid, [cyclohexyl[(4-methylphenyl)sulfonyl]methyl]-, 1,1-dimethylethyl ester
• CAS NO: 365441-86-7
• Molecular Formula: C19H29NO4S
• Molecular Weight: 367.51
• Mol File: 365441-86-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [cyclohexyl[(4-methylphenyl)sulfonyl]methyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [cyclohexyl[(4-methylphenyl)sulfonyl]methyl]-, 1,1-dimethylethyl ester(365441-86-7)
• EPA Substance Registry System: Carbamic acid, [cyclohexyl[(4-methylphenyl)sulfonyl]methyl]-, 1,1-dimethylethyl ester(365441-86-7)

Safety Data

• Hazardous Substances Data: 365441-86-7(Hazardous Substances Data)

Upstream product

• 4248-19-5 tert-butyl carbazate 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 2043-61-0 cyclohexanecarbaldehyde 

Downstream Products

• 1011258-58-4 diethyl [2-tert-butoxycarbonylamino-2-cyclohexyl-1-(diethoxyphosphoryl)ethyl]phosphonate 
• 1078719-40-0 (R)-tert-butyl cyclohexyl(dimethoxyphosphoryl)methylcarbamate 
• 1389318-59-5 tert-butyl cyclohexyl(1H-imidazol-1-yl)methylcarbamate 
• 1389318-60-8 tert-butyl (1H-benzo[d]imidazol-1-yl)(cyclohexyl)methylcarbamate 
• 1389318-61-9 tert-butyl (1H-benzo[d][1,2,3]triazol-1-yl)(cyclohexyl)methylcarbamate 
• 1389318-42-6 tert-butyl cyclohexyl(9H-purin-9-yl)methylcarbamate 
• 1389318-47-1 tert-butyl (4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)(cyclohexyl)methylcarbamate 
• 1389318-45-9 tert-butyl (2-chloro-9H-purin-9-yl)(cyclohexyl)methylcarbamate 
• 1389318-43-7 tert-butyl (6-chloro-9H-purin-9-yl)(cyclohexyl)methylcarbamate 
• 1389318-44-8 tert-butyl (2-amino-6-chloro-9H-purin-9-yl)(cyclohexyl)methylcarbamate 
• 1389318-41-5 tert-butylcyclohexyl(2,6-dichloro-9H-purin-9-yl)methyl-carbamate 
• 1389318-46-0 tert-butyl (2-chloro-6-methoxy-9H-purin-9-yl)(cyclohexyl)methylcarbamate 
• 1415650-26-8 (2,2-diiodo-1-phenyl-ethyl)-tert-butylcarbamate 
• 100049-94-3 ethyl 3-amino-3-cyclohexylpropanoate hydrochloride 

Relevant articles and documents

METTL3 INHIBITORY COMPOUNDS

The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X-Y-Z5 (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity 10 is implicated.

Reductive BOC-amination of aldehydes

Base-assisted elimination-reduction of α-amidoalkyl sulfones with sodium borohydride proceeds in tetrahydrofuran at room temperature leading to the corresponding BOC-amines in good yields.