365455-32-9

Upstream product

• 365455-27-2 O-(3,4-di-O-benzyl-2-deoxy-2-nitro-α-D-galactopyranosyl)-N-(tert-butyloxycarbonyl)-L-threonine tert-butyl ester 
• 145240-79-5 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-1-(methoxycarbonyl)-D-glycero-α-D-galacto-2-nonulopyranosyl diethyl phosphite 
• 365455-29-4 O-(3,4-di-O-benzyl-6-O-tert-butyldiphenylsilyl-2-deoxy-2-nitro-α-D-galactopyranosyl)-N-(tert-butyloxycarbonyl)-L-threonine tert-butyl ester 
• 365455-25-0 1,5-anhydro-3,4-di-O-benzyl-6-O-tert-butyldiphenylsilyl-2-deoxy-2-nitro-D-lyxo-hex-1-enitol 
• 201800-34-2 3,4-di-O-benzyl-6-O-(tert-butyldiphenylsilyl)-D-galactal 
• 30588-71-7 N-(tert-butyloxycarbonyl)-L-threonine tert-butyl ester 

Downstream Products

• 365455-34-1 N-(tert-butoxycarbonyl)-O-{O-[methyl(5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosyl)onate]-(2->6)-(2-acetamido-3,4-di-O-benzyl-2-deoxy-α-D-galactopyranosyl)}-L-threonine tert-butyl ester 

Relevant academic research and scientific papers

O-glycosyl amino acids by 2-nitrogalactal concatenation - Synthesis of a Mucin-type O-glycan

Base-promoted Michael-type addition of N-Boc- and N-Fmoc-protected serine and threonine esters to 2-nitrogalactal derivatives 2 and 26 led highly selectively to α-glycosides 4a-d and 27a,c, respectively. Ensuing transformation of threonine derivative 4d a

Nitroglycal concatenation: A broadly applicable and efficient approach to the synthesis of complex O-glycans

Base-catalyzed glycosylations provide the basis for a new and general entry to the synthesis of mucin-type O-glycans. The desired α-linked 2-acetamidoglycosyl amino acids B are accessible selectively starting from glycals of type A. Fmoc = 9-fluorenylmeth