365517-11-9

Upstream product

• 67-52-7 BARBITURIC ACID 
• 6334-18-5 2,3-dichlorobenzylaldehyde 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

Eco-friendly and efficient synthesis of pyrano[2,3-d] pyrimidinone and tetrahydrobenzo[b]pyran derivatives in water

Tetrahydrobenzo[b]pyran and pyrano[2,3-d]pyrimidinone derivatives were synthesized efficiently in the presence of KAl(SO4)2.12H2O (alum) in water. Green media, lack of toxicity, short reaction times, easy work-up and high yields are some advant

New advances in catalytic performance of erbium-folic acid-coated CoFe2O4 complexes for green one-pot three-component synthesis of pyrano[2,3-d]pyrimidinone and dihydropyrano[3,2-c]chromenes compounds in water

In the current research, much attention is paid to heterogenized nanostructure. Herein, we report the green synthesis magnetic nanoparticles (MNPs) of cobalt ferrite by the immobilization of erbium (Er) coated with folic acid (FA) which show effective cat

4,4'-trimethylenedipiperidine as a nitrogen heterocycle solvent and/or catalyst: Liquid phase tandem Knoevenagel-Michael condensation

Liquid phase tandem Knoevenagel-Michael condensation of various aromatic and heteroaromatic aldehydes with barbituric acid or 2-thiobarbituric acid and malononitrile was studied in a one-pot three-component reaction. For the first time, TMDP was employed as a safe and efficient solvent and/or catalyst in the liquid and aqueous ethanol medium, respectively, for the practical and eco-friendly Knoevenagel-Michael condensation. The reactions were carried out by using greener procedures, including a) the use of TMDP as an N-heterocycle organocatalyst in a green medium including water and ethanol (1:1 v/v) at reflux temperature, and b) the use of TMDP as a dual solvent-catalyst at 65 °C in the absence of any solvent. High to excellent yields of the desired pyrano[2,3-d] pyrimidinones were obtained under the two earlier mentioned conditions. The current methodologies have advantages, including (a) avoiding hazardous, toxic, volatile, and flammable materials and solvents, (b) avoiding tedious processes, harsh conditions, and multiple steps for the preparation of catalysts, (c) using a less toxic and noncorrosive catalyst, (d) minimizing hazardous waste generation and simple workup process, and (e) high recyclability of TMDP. Another important result of this work is that the TMDP can be a promising alternative for toxic, volatile, and flammable base reagents such as piperidine and triethylamine in liquid phase organic syntheses owing to its unique properties such as being less toxic, nonflammable, and nonvolatile, and having a low melting point, broad liquid range temperature, high thermal stability, and safe handling and storage.

Nano-ZnO Impregnated on Starch—A Highly Efficient Heterogeneous Bio-Based Catalyst for One-Pot Synthesis of Pyranopyrimidinone and Xanthene Derivatives as Potential Antibacterial Agents

Abstract: A new method has been proposed for the synthesis of pyranopyrimidinone andxanthene derivatives using zinc oxide–starch nanocomposite as catalyst undermicrowave irradiation. The ZnO–starch nanocomposite was characterized by X-raydiffraction and s

Nano-Zn[2-boromophenylsalicylaldiminemethylpyranopyrazole]Cl2 as a novel nanostructured Schiff base complex and catalyst for the synthesis of pyrano[2,3-d]pyrimidinedione derivatives

Nano-Zn[2-boromophenylsalicylaldiminemethylpyranopyrazole]Cl2 (nano-[Zn-2BSMP]Cl2) as a novel nanostructured Schiff base complex was prepared and characterized using several techniques. Nano-[Zn-2BSMP]Cl2 was used as an ef

Tetrabutylammonium bromide in water as a green media for the synthesis of pyrano[2,3-d]pyrimidinone and tetrahydrobenzo[b]pyran derivatives

Tetrabutylammonium bromide (TBAB) was used as a green catalyst for the synthesis of tetrahydrobenzo[b]pyran and pyrano[2,3-d]pyrimidinone derivatives in water as a solvent. Use of nontoxic reaction components, short reaction times, easy work-up and high y