365553-47-5

Upstream product

• 75-30-9 2-iodo-propane 
• 105640-07-1 4-(4-hydroxyphenyl)cyclohexan-1-one 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 868141-41-7 8-(4-isopropoxy-phenyl)-1,4-dioxa-spiro[4.5]decan-8-ol 
• 868141-71-3 8-(4-isopropoxy-phenyl)-1,4-dioxa-spiro[4.5]decane 

Downstream Products

• 868142-42-1 8-(4-isopropoxy-phenyl)-2,4-dioxo-1,3-diaza-spiro[4.5]decane-1,3-dicarboxylic acid di-tert-butyl ester 
• 868142-13-6 8-(4-isopropoxy-phenyl)-1,3-diaza-spiro[4.5]decane-2,4-dione 

Relevant academic research and scientific papers

Discovery of 1-amino-4-phenylcyclohexane-1-carboxylic acid and its influence on agonist selectivity between human melanocortin-4 and -1 receptors in linear pentapeptides

Linear pentapeptides (Penta-cis-Apc-DPhe-Arg-Trp-Gly-NH2) containing 1-amino-4-phenylcyclohexane-1-carboxylic acid (cis-Apc) and substituted Apc are potent hMC4R agonists and they are inactive or weakly active in hMC1R, hMC3R, and hMC5R agonist assays. This study, together with our earlier report on 5-BrAtc, demonstrated the importance of replacing His 6 with phenyl-containing rigid templates in achieving good hMC4R agonist potency and selectivity against hMC1R in linear pentapeptides.

Selective cyclic peptides with melanocortin-4 receptor (MC4-R) agonist activity

Peptides cyclized via disulfide or lactam bridges having melanocortin-4 receptor (MC4-R) agonist activity useful for treatment of obesity.

Selective linear peptides with melanocortin-4 receptor (MC4-R) agonist activity

Peptides of formulae I, II and III selectively activate melanocortin-4 (MC-4) receptor activity.