365564-39-2

Upstream product

• 2491-18-1 (S)-methyl 2-amino-4-(methylthio)butanoate hydrochloride 
• 100-52-7 benzaldehyde 
• 10332-17-9 Met-OMe 

Downstream Products

• 246870-40-6 {(S)-5-Benzylcarbamoyl-5-[(R)-2-(3,3-diphenyl-propionylamino)-2-(1H-indol-3-ylmethyl)-4-methylsulfanyl-butyrylamino]-pentyl}-carbamic acid benzyl ester 
• 246870-39-3 {(S)-5-Benzylcarbamoyl-5-[(S)-2-(3,3-diphenyl-propionylamino)-2-(1H-indol-3-ylmethyl)-4-methylsulfanyl-butyrylamino]-pentyl}-carbamic acid benzyl ester 
• 246870-29-1 [(S)-5-((S)-2-Benzyl-2-tert-butoxycarbonylamino-4-methylsulfanyl-butyrylamino)-5-benzylcarbamoyl-pentyl]-carbamic acid benzyl ester 
• 246870-30-4 [(S)-5-((R)-2-Benzyl-2-tert-butoxycarbonylamino-4-methylsulfanyl-butyrylamino)-5-benzylcarbamoyl-pentyl]-carbamic acid benzyl ester 
• 246870-26-8 2-(3,3-diphenyl-propionylamino)-2-(1H-indol-3-ylmethyl)-4-methylsulfanyl-butyric acid 
• 246870-24-6 2-(3,3-diphenyl-propionylamino)-2-(1H-indol-3-ylmethyl)-4-methylsulfanyl-butyric acid methyl ester 
• 246870-23-5 2-benzyl-2-tert-butoxycarbonylamino-4-methylsulfanyl-butyric acid methyl ester 
• 246870-25-7 2-benzyl-2-tert-butoxycarbonylamino-4-methylsulfanyl-butyric acid 
• 246870-21-3 2-amino-2-benzyl-4-methylsulfanyl-butyric acid methyl ester 
• 112674-76-7 (S)-4-Methylsulfanyl-2-[(3R,4S)-2-oxo-3-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-4-phenyl-azetidin-1-yl]-butyric acid methyl ester 

Relevant academic research and scientific papers

Platinum(II) and palladium(II) compounds containing chiral thioimines

A comparative study of the reactivity of the optically pure thioimine: (Sc)-(-)-C6H5-CH=N-CH (CO2Me)-CH2-CH2-SMe (1) versus platinum(II) and palladium(II) salts is reported. The reaction of 1 with cis-[PtCl2(dmso)2] leads to the cycloplatinated derivative (Sc,Rs)-(+)-[Pt {C6H4-CH=N-CH- (CO2Me)-CH2-CH2-SMe}Cl] (3a). The absolute configuration of 3a has been established unambiguously by X-ray diffraction: orthorhombic, with a = 8.979 (4), b = 9.605(9), c = 18.205(6) A, α = β = γ = 90.0°, space group P212121. Compound 3a contains a [6.5.6] tricyclic system generated by the fusion of a phenyl ring, a five-membered platinacycle and a six-membered chelate ring formed by the coordination of the nitrogen and sulfur to the platinum. When 1 was treated with Na2[PdCl4] in methanol at room temperature a (7.9:1) mixture of the two diastereomers {(Sc,Rs)-5a and (Sc,Ss)-5b} of cis-[Pd{C6H5-CH=N-CH (CO2Me)-CH2-CH2-SMe}Cl2] (5) was formed. However, when the reaction was performed in the presence of sodium acetate, the activation of the σ(Csp2,phenyl-H) bond took place giving the cyclopalladated complex: (Sc,Rs)-(+)- [Pd{C6H4-CH=N-CH (CO2Me)-CH2-CH2-SMe})Cl] (6a). In 6a, the ligand acts as a monoanionic (C,N,S)- terdentate group. The study of the reactivity of 3a and 6a with PPh3 is also reported.

Synthesis of novel proline and γ-lactam derivatives as non-peptide mimics of Somatostatin/Sandostatin

Original proline or γ-lactam derivatives bearing either an aryl group such as a phenyl or a 3-indolyl in position 3 of the proline moiety or on the 3-methyl chain of the γ-lactam skeleton were prepared as non-peptide mimics of Somatostatin/Sandostatin.