36598-30-8

Basic information

• Product Name: CYANIMIDODITHIOCARBONIC ACID S-BENZYL ESTER S-POTASSIUM SALT
• Synonyms: CYANIMIDODITHIOCARBONIC ACID S-BENZYL ESTER S-POTASSIUM SALT;Cyanimidodithiocarbonic acid S-benzyl ester
• CAS NO: 36598-30-8
• Molecular Formula: C₉H₇N₂S₂*K
• Molecular Weight: 246.39
• Mol File: 36598-30-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 215 °C
• Boiling Point: 327.2°C at 760 mmHg
• Flash Point: 151.7°C
• Appearance: /
• Vapor Pressure: 0.000206mmHg at 25°C
• CAS DataBase Reference: CYANIMIDODITHIOCARBONIC ACID S-BENZYL ESTER S-POTASSIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: CYANIMIDODITHIOCARBONIC ACID S-BENZYL ESTER S-POTASSIUM SALT(36598-30-8)
• EPA Substance Registry System: CYANIMIDODITHIOCARBONIC ACID S-BENZYL ESTER S-POTASSIUM SALT(36598-30-8)

Safety Data

• Hazardous Substances Data: 36598-30-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H8N2S2.K/c10-7-11-9(12)13-6-8-4-2-1-3-5-8;/h1-5H,6H2,(H,11,12);/q;+1/p-1

Upstream product

• 100-39-0 benzyl bromide 
• 13145-41-0 potassium cyanocarbonimidodithioate 

Downstream Products

• 39736-36-2 4-amino-2-benzylsulfanyl-thiazole-5-carboxylic acid ethyl ester 
• 63237-92-3 4-amino-2-benzylsulfanyl-thiazole-5-carboxylic acid amide 
• 85219-52-9 Benzyl-N-cyan(tetra-O-benzoyl-β-D-glucopyranosyl)dithiocarbimidat 
• 67944-62-1 3t-(4-amino-2-benzylsulfanyl-thiazol-5-yl)-acrylonitrile 
• 36950-14-8 3-chloro-5-phenylmethanesulfinyl-[1,2,4]thiadiazole 
• 36950-21-7 3-chloro-5-phenylmethanesulfonyl-[1,2,4]thiadiazole 
• 87789-33-1 2-Benzylsulfanyl-4H-thiazolo[4,5-d]pyrimidine-5,7-dione 
• 87789-39-7 2-Benzylsulfanyl-5,7-dichloro-thiazolo[4,5-d]pyrimidine 
• 87789-27-3 (4-Amino-2-benzylsulfanyl-thiazole-5-carbonyl)-carbamic acid ethyl ester 
• 85219-60-9 2,3-Bis<<(benzylthio)(cyanimino)methyl>thiomethyl>chinoxalin 
• 63238-22-2 [3-(3-nitro-phenyl)-4-oxo-thiazolidin-2-ylidene]-cyanamide 
• 63238-18-6 4-amino-2-benzylsulfanyl-thiazole-5-carboxylic acid N-methyl-anilide 
• 63238-07-3 4-amino-2-benzylsulfanyl-thiazole-5-carboxylic acid diethylamide 
• 60301-47-5 bis-(4-amino-2-benzylsulfanyl-thiazol-5-yl)-methanone 

Relevant articles and documents

Design and Synthesis of Novel Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors with the Ability to Rescue Auditory Gating Deficit in Mice

A series of novel thiazolo[4,5-d]pyrimidin-7(6H)-ones (3aa-3eq) were designed, synthesized, and evaluated as the type I positive allosteric modulators of human α7 nAChR expressed in Xenopus ooctyes by a two-electrode voltage clamp. The structure-activity relationship analysis identified the compound 3ea as a potent and efficacious PAM with the maximum activation effect of the α7 current of over 1633% in the presence of acetylcholine (100 μM) and an EC50 = 1.26 μM. It is highly specific to α7 nAChR over other subtypes of nAChR, 5-HT3A, NMDA, and GABAA receptors. Compound 3ea showed an elimination half-life of 10.8 ± 1.5 h for 3 mg/kg, i.v., and 7.4 ± 1.1 h for 60 mg/kg, i.g. in rat. It also exhibited sufficient blood-brain barrier penetration with no significant effect on hERG channel. Most importantly, compound 3ea dose-dependently (0.1-1 mg/kg, i.p.) reversed the prepulse inhibition deficit induced by MK-801 in the mouse schizophrenia model.