36598-86-4

Basic information

• Product Name: methylphosphoramidic dichloride
• Synonyms: Methylphosphoramidic dichloride; phosphoramidic dichloride, N-methyl-
• CAS NO: 36598-86-4
• Molecular Formula: CH₄Cl₂NOP
• Molecular Weight: 147.9283
• Mol File: 36598-86-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 163.5°C at 760 mmHg
• Flash Point: 52.7°C
• Density: 1.467g/cm³
• Vapor Pressure: 2.06mmHg at 25°C
• Refractive Index: 1.445
• PKA: -5.77±0.70(Predicted)
• CAS DataBase Reference: methylphosphoramidic dichloride(CAS DataBase Reference)
• NIST Chemistry Reference: methylphosphoramidic dichloride(36598-86-4)
• EPA Substance Registry System: methylphosphoramidic dichloride(36598-86-4)

Safety Data

• Hazardous Substances Data: 36598-86-4(Hazardous Substances Data)

Upstream product

• 593-51-1 methylamine hydrochloride 

Downstream Products

• 110638-51-2 (3S,7aS)-1,2,5,6,7,7a-hexahydro-3-(methylamino)-2-phenylpyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide 
• 110715-37-2 (3R,7aS)-1,2,5,6,7,7a-hexahydro-3-(methylamino)-2-phenylpyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide 
• 77202-86-9 C₇H₉ClNO₂P 
• 82960-74-5 C₇H₈ClN₂O₄P 
• 10159-46-3 Pentamethylphosphorsaeuretriamid 
• 6186-07-8 Dichlormethylen-amidophosphorsaeure-dichlorid 
• 39564-20-0 CH₃Cl₂F₂NOP₂S 
• 29777-25-1 Chlorophenylphosphinyl-(dichlorophosphinyl)-methylamin 

Relevant articles and documents

Amido phosphate bis-curcumin ester compound, preparation method and application

The invention discloses an amido phosphate bis-curcumin ester compound, a preparation method and application, and belongs to the field of medicinal chemistry. The compound has the structural formula as follows (referring to the description). The R1 and R2 in the formula (I) can form a saturated nitrogen heterocyclic ring structure as follows through cyclization (referring to the description). The preparation method of the compound comprises the following steps: firstly, preparing amino phosphoryl chloride or thio amino phosphoryl chloride; then reacting with curcumin to obtain the compound. The amido phosphate bis-curcumin ester compound provided by the invention has relatively good antineoplastic activity, the toxicity of the compound is smaller than that of cisplatin, and the compound can be used for preparing medicine for resisting lung cancer, stomach cancer, leukemia, breast cancer and inflammation.

Synthesis of Phenyl Phosphorodiamidates

Two procedures are described for the synthesis of phenyl phosphorodiamidates in high yields.These compounds can be represented by the general formula 6 and are used for cyclisation reactions leading to phosphabarbituric acids.