10159-46-3

Basic information

• Product Name: pentamethylphosphoramide
• Synonyms: pentamethylphosphoramide
• CAS NO: 10159-46-3
• Molecular Formula: C5H16 N3 O P
• Molecular Weight: 165.17
• Mol File: 10159-46-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 197.6°Cat760mmHg
• Flash Point: 73.3°C
• Appearance: /
• Density: 1.041g/cm³
• Vapor Pressure: 0.375mmHg at 25°C
• Refractive Index: 1.456
• CAS DataBase Reference: pentamethylphosphoramide(CAS DataBase Reference)
• NIST Chemistry Reference: pentamethylphosphoramide(10159-46-3)
• EPA Substance Registry System: pentamethylphosphoramide(10159-46-3)

Safety Data

• Hazardous Substances Data: 10159-46-3(Hazardous Substances Data)

Usage

General Description

Pentamethylphosphoramide, also known as PMPA, is a highly polar and toxic organic compound that is commonly used as a solvent in organic chemistry reactions and as a reagent in metal-catalyzed transformations. It is a colorless, odorless liquid that is highly reactive with water and air, making it challenging to handle safely. PMPA is classified as a carcinogen and mutagen, posing potential health risks to humans, and it is also harmful to the environment due to its toxic nature. Despite its dangers, PMPA is valued for its unique chemical properties and is used in various industrial and research applications. Proper handling and disposal procedures are essential to minimize the risks associated with this chemical.

InChI:InChI=1/C5H16N3OP/c1-6-10(9,7(2)3)8(4)5/h1-5H3,(H,6,9)

Upstream product

• 680-31-9 N,N,N,N,N,N-hexamethylphosphoric triamide 
• 36598-86-4 N-methylphosphoroamidodichloridate 
• 124-40-3 dimethyl amine 
• 1605-65-8 N,N,N',N'-Tetramethylphosphorodiamidic chloride 
• 74-89-5 methylamine 
• 20583-06-6 N--N-methylformamid 

Downstream Products

• 26400-27-1 Hydroxymethylpentamethylphosphorsaeuretriamid 
• 20583-06-6 N--N-methylformamid 

Relevant articles and documents

Insect chemosterilants. VI. Oxidation of hexamethylphosphoric triamide and the synthesis of N-formylphosphoramides.

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Thermal Oxidative Deamination of Aliphatic Amines to Aldehydes with Bis(diphenylphosphinyl) Peroxide

Reaction of N-substituted alkylamines having pseudoacidic hydrogen at the 1-methylene group with bis(diphenylphosphinyl) peroxide yields the deaminated products by thermal elimination of diphenylphosphinic acid from the intermediate O-diphenylphosphinylhydroxylamines.

Aminomethylation of N-propargylphosphoramides. Synthesis of unsymmetrical acetylenic diamines

The preparation of N-alkyl-N-(4-dialkylamino-2-butylnyl)phosphoramides 3 using the Mannich reaction is described.The acidic hydrolysis of those phosphoramides leads to unsymmetrical acetylenic diamines 4.