365996-19-6

Basic information

• Product Name: Carbamic acid, [(1R,2S)-2-aminocyclopentyl]-, 1,1-dimethylethyl ester, rel-
• Synonyms: Carbamic acid, [(1R,2S)-2-aminocyclopentyl]-, 1,1-dimethylethyl ester, rel-;Cis-tert-butyl 2-aminocyclopentyl)carbamate;(1S,2R)-2-AMINO-1-(N-BOC-AMINO)CYCLOPENTANE
• CAS NO: 365996-19-6
• Molecular Formula: C₁₀H₂₀N₂O₂
• Molecular Weight: 200.28
• Product Categories: CYCLOPENTANE;N-BOC
• Mol File: 365996-19-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, [(1R,2S)-2-aminocyclopentyl]-, 1,1-dimethylethyl ester, rel-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1R,2S)-2-aminocyclopentyl]-, 1,1-dimethylethyl ester, rel-(365996-19-6)
• EPA Substance Registry System: Carbamic acid, [(1R,2S)-2-aminocyclopentyl]-, 1,1-dimethylethyl ester, rel-(365996-19-6)

Safety Data

• Hazardous Substances Data: 365996-19-6(Hazardous Substances Data)

Upstream product

• 1330069-67-4 trans-N-(2-hydroxycyclopentyl)carbamic acid tert-butyl ester 
• 33092-86-3 trans-2-aminocyclopentanol 
• 285-67-6 Cyclopentene oxide 

Downstream Products

• 1517-69-7 (R)-1-phenylethanol 
• 1205616-17-6 tert-butyl (1S,2R)-[(2-acetylamino)cyclopentyl]carbamate 
• 721395-15-9 (1S,2R)-2-(N-t-butyloxycarbonylamino)-1-aminocyclopentane 
• 445479-01-6 (1R,2S)-2-tert-Butoxycarbonylaminocyclopentylamine 

Relevant articles and documents

FGFR INHIBITORS FOR THE TREATMENT OF CANCER

The disclosure provides novel FGFR inhibitors based on the pyridinylpyrimidine. The disclosure includes inhibitors with broad inhibitory activity against all FGFR isoforms, and inhibitors with selective inhibition against FGFR4. These novel pyridinylpyrimidine-based FGFR inhibitors, or their derivatives, have strong potential to be used to treat cancer.

Enzymatic dynamic kinetic resolution of (±)-cis-N-(Alkoxycarbonyl) cyclopentane-1,2-diamines based on spontaneous racemization

Lipase B from Candida antarctica is an excellent catalyst for the enantioselective acetylation of different (±)-cis-N-(alkoxycarbonyl) cyclopentane-1,2-diamines. Depending on the alkoxycarbonyl group, a simple kinetic resolution (Boc-derivative) or an interesting dynamic kinetic resolution (DKR with Cbz-, Alloc, and ethoxycarbonyl derivatives) has been developed. Racemization for the DKR occurred due to the N,N′ intramolecular migration of the alkoxycarbonyl group.