366014-82-6Relevant academic research and scientific papers
Improved addition of organolithium reagents to hindered and/or enolisable ketones
Lecomte, Vincent,Stéphan, Elie,Le Bideau, Franck,Jaouen, Gérard
, p. 2169 - 2176 (2003)
A study of the addition of some aryl- and alkyllithium derivatives to some hindered and/or enolisable ketones in different solvents (polar and apolar) and, in some cases, at different temperatures and reaction times, will be presented here. The reversibility of the addition of aryllithium to these specific ketones will be observed and discussed. This approach is then used to prepare new steroids as precursor for potentially interesting substituted testosterones.
Addition of aryllithiums to an 11-oxo-steroid
Lecomte, Vincent,Foy, Nicolas,Le Bideau, Franck,Stéphan, Elie,Jaouen, Gérard
, p. 5409 - 5411 (2007/10/03)
The addition of aryllithiums to an 11-oxo-steroid is possible in non-polar medium and at room temperature. A series of protected 11α-aryl-11β-hydroxy-androsten-diones have been prepared.
