366014-92-8

Upstream product

• 333-20-0 potassium thioacyanate 
• 36817-92-2 5-(2-hydroxy-phenyl)-1⁽²⁾H-pyrazole-3-carboxylic acid hydrazide 

Downstream Products

• 366015-00-1 2-[5-(5-mercapto-4H-[1,2,4]triazol-3-yl)-1H-pyrazol-3-yl]-phenol 

Relevant academic research and scientific papers

Synthesis and antimicrobial study of heterocyclyl substituted s-triazoles, 1,3,4-thiadiazoles, oxadiazoles and related heterocycles

Cyclocondensation reaction of 1-(3-aryl-1H-5-pyrazol-5-yl)-4-substituted thiosemicarbazides 2a-d with 2N KOH solution yields s-triazoles 3a-h while with hot anhydrous ortho-phosphoric acid gives 2-(3-aryl-1H-pyrazol-5-yl)-5-amino-1,3,4-thiadiazoles 4a-h. Oxidative cyctisation of 2a-h with I2/KI in alkaline condition affords 1.3.4- oxadiazoles 5a-h. Some of the thiosemicarbazides 2a-d on reaction with CS2/DMF under reflux result in the formation of 5-(3-aryl-1H-pyrazol-5-yl)-2-mercapto-1,3,4-thia-diazoles 6a-h. Similarly, triazoles 3a-d with α-chloroacetic acid in the presence of fused sodium acetate yield thiazolo-s-triazolones 7a-d. The structures of these compounds have been established on the basis of their elemental analysis and spectral data and evaluated for their antimicrobial activity against gram-negative and gram-positive bacteria.