36611-98-0Relevant academic research and scientific papers
New multi-site phase transfer catalyst for the addition of dichlorocarbene to olefins
Shanmugan,Balakrishnan
, p. 1069 - 1074 (2008/02/11)
Three step synthesis of a new, water-soluble multi-site phase transfer catalyst (MPTC-I), viz., α,α1,α11- tris(triethyl ammonium methylene bromide) β-hydroxy ethyl benzene is described. The potentiality of MPTC-I is demonstrated by studying kinetic aspects of the reactions, viz. dichlorocarbene addition to styrene, α-methyl styrene and trans-stilbene.
Biological evaluation of novel cyclopropyl analogues of stilbene, stilbenediol, and phenanthrene for estrogenic and antiestrogenic activity
Pento,Koenig,Magarian,Kosanke,Gilliland
, p. 120 - 125 (2007/10/02)
The triphenylethylene-type antiestrogens, such as tamoxifen, are known to be useful in the treatment of estrogen-dependent tumors. However, these compounds display mixed estrogen agonist/antagonist activity which may limit their therapeutic effectiveness. This problem of mixed activity led to the synthesis and identification of a cyclopropyl derivative of cis-stilbene which we have named Analog I. This compound (1,1-dichloro-cis-2,3-diphenylcyclopropane) displayed only antiestrogenic activity in the mouse. The present study was designed to evaluate cyclopropyl derivatives of Analog II for estrogenic and antiestrogenic activity in the rate using the standard 3-d uterotropic assay and the uterine cytoplasmic estrogen receptor assay. Five compounds (B-F) which are cyclopropyl derivatives of stilbene, stilbenediol, and phenanthrene were evaluated in this study. Three of the compounds (B-D) displayed neither estrogenic nor antiestrogenic activity in the rat. The relative estrogenic activities of E and F were 11.3 and 1.5%, respectively, of diethylstilbestrol in the uterotropic assay, and 39 and 6.2%, respectively, of estradiol in the estrogen receptor assay. Neither E nor F was found to display antiestrogenic activity in the rat. The results indicate that the relative estrogenic and receptor binding activities of E and F are similar to those previously observed in the mouse, while B-D appear to be inactive in both species.
COPOLYESTERAMIDES CONTAINING POLY(ETHYLENE OXIDE) SOFT SEGMENTS AS NEW AND EFFICIENT PHASE-TRANSFER CATALYSTS
Montanari, Fernando,Penso, Michele,Fortuna, Giorgio della,Re, Alberto
, p. 427 - 432 (2007/10/02)
Copolyesteramides, 1, prepared by melt polycondensation of N,N'-bis(4-methoxycarbonylbenzoyl)hexamethylenediamine, 2, 1,6-hexanediol and poly(ethylene glycol) (PEG 1000), are a new class of polymeric phase-transfer catalysts.Their catalytic activity has been tested in nucleophilic aliphatic substitutions, eliminations, alkylations of activated methylene groups, dichlorocyclopropanation of C=C double bonds, reductions of ketones to alcohols and oxydation of primary alcohols to aldehydes.
Synthesis of clyclopropyl analogs of stilbene and stilbenediol as possible antiestrogens.
Magarian,Benjamin
, p. 1626 - 1632 (2007/10/12)
Conformationally rigid analogs of stilbene and stilbenediol were prepared via gem-dichlorocyclopropyl precursors utilizing two different synthetic methods: a two-phase catalytic method and an organomercurial method. These precursors were reduced to the corresponding cyclopropyl analogs using sodium and methanol. All compounds are being tested to discriminate between estrogenic and antiestrogenic ability, to determine estrogen binding ability, and to evaluate tissue culture anticancer activity.
