3663-33-0Relevant academic research and scientific papers
Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis
Wang, Xiaoyu,Zhao, Rui,Ji, Wenming,Zhou, Jie,Liu, Quan,Zhao, Linxiang,Shen, Zhufang,Liu, Shuainan,Xu, Bailing
supporting information, p. 118 - 127 (2022/01/03)
Liver fructose-1,6-bisphosphatase (FBPase) is a key enzyme in the gluconeogenesis, and its inhibitors are expected to be novel antidiabetic agents. Herein, a series of new indole and benzofuran analogues were designed and synthesized to evaluate the inhib
Concise total synthesis of
Buszek, Keith R.,Brown, Neil,Luo, Diheng
supporting information; experimental part, p. 201 - 204 (2009/06/20)
An efficient nine-step total synthesis of the annulated indole natural products.
Heterocyclic compounds as inhibitors of factor VIIa
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Page/Page column 83, (2008/06/13)
The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel heterocyclic compounds, or a stereoisomer or pharmaceutically acceptable salt, solvate, or prodrug form thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.
