3663-52-3

Basic information

• Product Name: BIS(TRIMETHYLSILYL) PHOSPHITE
• Synonyms: BIS(TRIMETHYLSILYL) PHOSPHITE
• CAS NO: 3663-52-3
• Molecular Formula: C₆H₁₉O₃PSi₂
• Molecular Weight: 226.36
• Product Categories: Organic Building Blocks;Organic Phosphates/Phosphites;Phosphorus Compounds;Building Blocks;Chemical Synthesis;Organic Building Blocks;Organic Phosphates/Phosphites;Phosphorus Compounds
• Mol File: 3663-52-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 77-79 °C11 mm Hg
• Flash Point: 58 °C
• Appearance: /
• Density: 0.968 g/mL at 20 °C(lit.)
• Refractive Index: n20/D 1.412
• Storage Temp.: 2-8°C
• CAS DataBase Reference: BIS(TRIMETHYLSILYL) PHOSPHITE(CAS DataBase Reference)
• NIST Chemistry Reference: BIS(TRIMETHYLSILYL) PHOSPHITE(3663-52-3)
• EPA Substance Registry System: BIS(TRIMETHYLSILYL) PHOSPHITE(3663-52-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 3663-52-3(Hazardous Substances Data)

Usage

Uses

Bis(trimethylsilyl) Phosphite is used in the Todd-Atherton synthetic approach for chemical modification of tetraene macrolide antibiotic lucensomycina. It is also used as a reagent in the preparation of mono-and diphosphorus proline derivatives.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 1795-31-9 tris(trimethylsilyl) phosphite 
• 2491-15-8 formylglycine 
• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 30148-50-6 bis(trimethylsilyl)phosphonite 
• 762-72-1 allyl-trimethyl-silane 
• 620-05-3 iodomethylbenzene 
• 104971-41-7 methoxy(trimethylsilyloxy)phosphine 

Downstream Products

• 1795-31-9 tris(trimethylsilyl) phosphite 
• 1448989-20-5 (2-furyl)-N-(4-methoxyphenyl)aminomethylphosphonic acid 
• 1448989-22-7 (2-furyl)-N-(diphenylmethyl)aminomethylphosphonic acid 
• 1448989-21-6 (2-furyl)-N-(4-methylphenyl)aminomethylphosphonic acid 
• 1416767-26-4 C₂₂H₅₀O₁₀P₂SSi₅ 
• 1227665-14-6 tris(trimethylsilyl) N-aminomethylene diphosphonite 
• 1227665-11-3 O,O',O'',O'''-tetra(trimethylsilyl) N-anilinomethylenebisphosphonate 
• 65868-47-5 C₁₆H₃₈ClO₄PSi₃ 
• 65868-39-5 C₁₄H₂₄BrO₄PSi₂ 
• 76613-01-9 bis(trimethylsilyl) 1-(trimethylsiloxy)-1-methyl-hexylphosphonate 
• 65868-41-9 Bis-(trimethylsilyl)-1-(4-brom-phenyl)-vinylphosphat 

Relevant articles and documents

Organosilicon based synthesis of new functionalized aminomethylenediphosphonates with moieties of amino acids

The new functionalized aminomethylenediphosphonates with moieties of various amino acids are synthesized via unique reaction of tris(trimethylsilyl) phosphite and N-formyl amino acids at the presence of effective catalyst – trimethylsilyl triflate under m

Hydrophosphonylation of Alkynes with Trialkyl Phosphites Catalyzed by Nickel

The use of simple and inexpensive NiCl2?6 H2O as a catalyst precursor for C?P bond formation in the presence of commercially available trialkyl phosphites (P(OR)3, R=Et, iPr, Bu, SiMe3) along with several alkynes is presented. Control experiments showed the in situ formation of (RO)2P(O)H as the species that undergo the addition into the C≡C bond at the alkynes to yield the product of P?H addition. The hydrophosphonylation of diphenylacetylene with P(OEt)3, P(OiPr)3, and P(OSiMe3)3 proceeds in high yields (>92 %) without the need of a specific solvent or ligand. This method is useful for the preparation of organophosphonates for both phenylacetylene as a terminal alkyne model and internal alkynes in yields that range from good to modest.

Reaction of bis(trimethylsiloxy)phosphine with trimethylsilane

Bis(trimethylsilyl) [3-(trimethylsilyl)propyl]phosphonate and trimethylsilyl [3-(trimethylsilyl)propyl]-phosphinate are obtained by the reaction of bis(trimethylsiloxy)phosphine with trimethylallylsilane and converted into [3-(trimethylsilyl)propyl]phosphinic and [3-(trimethylsilyl) propyl]phosphonic acid, respectively, by the reaction with methanol.