36638-57-0

Usage

Structure

Contains a cyclopropane ring and a phenylthio group attached to the carbon of the carboxylic acid

Type of compound

Carboxylic acid derivative

Potential applications

Organic synthesis and medicinal chemistry

Safety precautions

Handle with care and follow proper safety guidelines in a laboratory setting

Upstream product

• 36638-53-6 1-cyano-1-thiophenyl cyclopropane 
• 124-38-9 carbon dioxide 
• 28118-53-8 1,3-bis(phenylthio)propane 
• 5219-61-4 (phenylthio)acetonitrile 
• 342624-00-4 methyl 1-(phenylthio)cyclopropanecarboxylate 

Relevant academic research and scientific papers

Amido compounds and their use as pharmaceuticals

The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor MR, and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.

A New and Convenient Synthetic Method for Cyclopropyl Phenyl Sulfides

The reactions of a variety of 1,3-bis(phenylthio)propanes with butyllithium have been shown to produce cyclopropyl phenyl sulfides in good to high yields.A new and convenient in situ preparation of 1-lithiocyclopropyl phenyl sulfide can be readily carried out by treating 1,3-bis(phenylthio)propane with 2 equiv. of butyllithium at 0 degC in THF.The reaction with electrophiles proceeds in good yield.O-Aryl and O-alkyl S-cyclopropyl dithiocarbonates also can be prepared in good yields. 1,2-Bis(phenylthio)ethane was converted to phenyl vinyl sulfide on treatment with butyllithium, while 1,4-bis(phenylthio)butane was recovered unchanged by a similar treatment.