3664-75-3Relevant academic research and scientific papers
Copper-Catalyzed Conjugate Addition of Trimethylaluminium to α,β-Unsaturated Ketones
Kabbara, Jazid,Flemming, Steffen,Nickisch, Klaus,Neh, Harribert,Westermann, Juergen
, p. 1489 - 1494 (2007/10/02)
The conjugate methylation of α,β-unsaturated ketones with trimethylaluminium occurs smoothly in a very simple procedure under the catalytic CuI salts.Scope and limitations of this process as well as the influence of solvent and catalyst on the kinetics were studied.In addition, the effect of chlorotrimethylsilane as an additive was investigated.Attack on the carbonyl group in 1,2-fashion could not be observed under the reaction conditions.- Key Words: Conjugate alkylation / Trimethylaluminium / Copper catalysis
REACTIONS OF STOICHIOMETRIC HIGHER ORDER, MIXED LITHIO MAGNESIO ORGANOCUPRATES
Lipshutz, Bruce H.,Parker, David A.,Nguyen, Sam L.,McCarthy, Keith E.,Barton, John C.,et al.
, p. 2873 - 2880 (2007/10/02)
Novel higher order cuprates, R(2-thienyl)Cu(CN)LiMgBr (2), are prepared from the 1:1:1 combination of CuCN, 2-lithiothiophene and RMgX.Reactions of various members of this new class of reagents are described, including substitution and conjugate addition processes, where the ligand derived from the Grignard reagent is selectively transferred.The effects of added BF3*Et2O are discussed.Some comparison reactions with the corresponding lower order reagents, RCu(CN)MgBr, have also been carried out.Evidence is presented suggesting that species 2, unlike their dilithio analogs, are not discrete.
