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3-Hydroxy-6-cholen-24-oic acid is a steroidal compound characterized by the presence of a hydroxyl group at the 3rd carbon and a carboxylic acid group at the 24th carbon of the cholestane skeleton. This molecule is part of the bile acid family, which plays a crucial role in the digestion and absorption of dietary fats and fat-soluble vitamins in the human body. Bile acids are synthesized in the liver from cholesterol and are then stored in the gallbladder before being released into the small intestine to aid in digestion. 3-Hydroxy-6-cholen-24-oic acid, in particular, is a minor bile acid that contributes to the overall function of the bile acid pool, helping to maintain cholesterol homeostasis and facilitate the emulsification of fats for absorption.

3664-87-7

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3664-87-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3664-87-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,6,6 and 4 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 3664-87:
(6*3)+(5*6)+(4*6)+(3*4)+(2*8)+(1*7)=107
107 % 10 = 7
So 3664-87-7 is a valid CAS Registry Number.
InChI:InChI=1/C24H38O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h5-6,15-21,25H,4,7-14H2,1-3H3,(H,26,27)/t15-,16-,17-,18+,19-,20+,21+,23+,24-/m1/s1

3664-87-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 3α-hydroxy-5β-chol-6-en-24-oic acid

1.2 Other means of identification

Product number -
Other names 3α-Hydroxy-5β-chol-6-en-24-saeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3664-87-7 SDS

3664-87-7Relevant academic research and scientific papers

Reduction of 3α-hydroxy-5β-chol-6-en-24-oic acid to lithocholic acid in rats

Kimura, Koji,Ogura, Michio

, p. 337 - 348 (1988)

After Δ6-lithocholic acid was injected into the cecum of rats, lithocholic acid was identified as a metabolite in feces.When the labeled Δ6-bile acid was injected intraperitoneally into bile-fistula rats, radioactivity excreted in bile was contained most abundantly in the taurine-conjugated fraction of bile acids.In the fraction, taurine conjugate of Δ6-lithocholic acid but of neither lithocholic acid nor other bile acids was found.The results showed that Δ6-lithocholic acid was reduced to lithocholic acid by intestinal flora but not by the liver, which, however, was capable of conjugating Δ6-lithocholic acid with taurine.

Synthesis of 5 beta-cholestane-3 alpha,6 beta,7 alpha,25,26-pentol and identification of a novel bile alcohol, alpha-trichechol, present in the West Indian manatee bile.

Yoshii,Une,Kihira,Kuramoto,Hoshita

, p. 1852 - 1854 (2007/10/02)

In order to confirm the structure of alpha-trichechol, the major bile alcohol of the West Indian manatee, chemical synthesis of 5 beta-cholestane-3 alpha,6 beta,7 alpha,25,26-pentol was carried out. The chain of 3 alpha-hydroxy-5 beta-chol-6-en-24-oic acid was elongated by an Arndt-Eistert reaction to form 3 alpha-hydroxy-26,27-dinor-5 beta-cholest-6-en-25-oic acid. The unsaturated C25 bile acid was converted into 3 alpha,6 beta,7 alpha-trihydroxy-25-homo-5 beta-cholan-25-oic acid by 1,2-glycol formation of the delta 6-double bond. The acetylated derivative of the trihydroxy C25 bile acid was then converted into 3 alpha,6 beta,7 alpha,26-tetraacetoxy-27-nor-5 beta-cholestan-25-one by successive treatment with thionyl chloride, diazomethane, and acetic acid. A Grignard reaction of the 25-oxo compound with methylmagnesium iodide afforded the desired bile alcohol, 5 beta-cholestane-3 alpha,6 beta,7 alpha,25,26-pentol. By direct comparison with the synthetic pentahydroxy bile alcohol, the structure of the naturally occurring alpha-trichechol was determined to be 5 beta-cholestane-3 alpha,6 beta,7 alpha,25,26-pentol.

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