36640-47-8

Basic information

• Product Name: 1-(4-Fluorophenyl)-3-phenyl-1H-pyrazole-4-carboxaldehyde
• Synonyms: 1-(4-Fluorophenyl)-3-phenyl-1H-pyrazole-4-carboxaldehyde
• CAS NO: 36640-47-8
• Molecular Formula: C₁₆H₁₁FN₂O
• Molecular Weight: 266.2697432
• Mol File: 36640-47-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 171～173℃
• Appearance: /
• CAS DataBase Reference: 1-(4-Fluorophenyl)-3-phenyl-1H-pyrazole-4-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Fluorophenyl)-3-phenyl-1H-pyrazole-4-carboxaldehyde(36640-47-8)
• EPA Substance Registry System: 1-(4-Fluorophenyl)-3-phenyl-1H-pyrazole-4-carboxaldehyde(36640-47-8)

Safety Data

• Hazardous Substances Data: 36640-47-8(Hazardous Substances Data)

Usage

Description

1-(4-Fluorophenyl)-3-phenyl-1H-pyrazole-4-carboxaldehyde is a chemical compound with the molecular formula C16H11FN2O. It is a pyrazole derivative featuring a fluorophenyl group and a phenyl group attached to a pyrazole ring. 1-(4-Fluorophenyl)-3-phenyl-1H-pyrazole-4-carboxaldehyde, classified as a carboxaldehyde, contains both an aldehyde group and a carboxyl group. Its chemical structure and properties render it a versatile intermediate in the synthesis of pharmaceuticals and agrochemicals, making it a valuable asset in medicinal chemistry for the development of novel drugs. Furthermore, its aromatic structure suggests potential utility as a reagent in organic synthesis and as a precursor for other chemical compounds.

Uses

Used in Pharmaceutical Industry:
1-(4-Fluorophenyl)-3-phenyl-1H-pyrazole-4-carboxaldehyde is used as an intermediate in the synthesis of various pharmaceuticals due to its unique chemical structure and properties. Its ability to be incorporated into the development of new drugs makes it a crucial component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(4-Fluorophenyl)-3-phenyl-1H-pyrazole-4-carboxaldehyde serves as an intermediate for the synthesis of agrochemicals, contributing to the development of new products for agricultural applications.
Used in Organic Synthesis:
1-(4-Fluorophenyl)-3-phenyl-1H-pyrazole-4-carboxaldehyde is used as a reagent in organic synthesis, taking advantage of its aromatic structure and functional groups to facilitate the creation of a range of chemical compounds.
Used as a Precursor for Other Chemical Compounds:
Due to its structural features, 1-(4-Fluorophenyl)-3-phenyl-1H-pyrazole-4-carboxaldehyde is also used as a precursor for the synthesis of other chemical compounds, expanding its utility in the chemical industry.

Upstream product

• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 68-12-2 N,N-dimethyl-formamide 
• 399-19-9 1-(4-fluorophenyl)-2-(1-phenylethylidene)hydrazine 
• 98-86-2 acetophenone 

Relevant articles and documents

Substituted imidazole-pyrazole clubbed scaffolds: Microwave assisted synthesis and examined their in-vitro antimicrobial and antituberculosis effects

A series of substituted imidazole-pyrazole fused compounds were designed & fused synthesized by employing Debus-Radziszewski one-pot synthesis reaction. Azoles are an extensive and comparatively new class of synthetic compounds including imidazoles and pyrazoles. The current clinical treatment uses compounds of azole framework. Azoles act by inhibiting ergosterol synthesis pathway (a principal component of the fungal cell wall). In addition, a literature review shows that the compounds that include imidazoles and pyrazoles have significant anti-bacterial and anti-mycobacterial effects. In light of the above findings, a series of compounds with imidazole and pyrazole scaffolds were sketched and developed to examine anti-bacterial, antifungal and anti-mycobacterial activities. The structures of the synthesized compounds were characterized using1HNMR,13CNMR, elemental analysis, and MS spectral data. The target compounds were screened for their in-vitro antimicrobial activity against gram-positive and gram-negative bacterial species by disc diffusion method according to the NCCLS (National Committee for Clinical Laboratory Standards) and anti-mycobacterial activity against the Mycobacterium tuberculosis H37Rv strain. The results revealed that imidazole-pyrazole fused scaffold compounds have potential anti-bacterial, antifungal and anti-mycobacterial activities which can be further optimized to get a lead compound.

Discovery of novel double pyrazole Schiff base derivatives as anti-tobacco mosaic virus (TMV) agents

Many pyrazole derivatives were reported to exhibit highly activity towards tobacco mosaic virus (TMV). In this work, an optimized pyrazole Schiff base scaffold was designed and introduced to derive novel potential TMV inhibitors. Thirty-six compounds were synthesized, characterized by elemental analysis, mass spectra and nuclear magnetic resonance (NMR) spectroscopy and evaluated by biological experiments. The bioassay results showed that some of the synthesized compounds exhibited excellent anti-TMV activities. Especially, 5-chloro-3-methyl-1H-pyrazole contained compound 4j showed ningnanmycin comparable inhibitory activity and can be considered as potential anti-TMV candidate agent. With molecular docking, compound 4j insert into nucleotide sequence (GAAGUU) of OriRNA stably which revealed nucleotide could be a target of these compounds.

A mild procedure for the preparation of 3-aryl-4-formylpyrazoles

A variety of 3-aryl-4-formylpyrazoles can be easily prepared in good yields from the corresponding methyl ketones, upon treatment with 2,4,6-trichloro[1,3, 5]triazine in N,N-dimethyl formamide at room temperature. This kind of pyrazole can constitute new building blocks for combinatorial chemistry.