366453-21-6

Usage

Uses

Used in Pharmaceutical Industry:
1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy(9CI) is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure and properties make it a valuable component in the development of new therapeutic agents.
Used in Organic Synthesis:
1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy(9CI) is used as a key building block in organic synthesis for the preparation of complex organic molecules. Its reactivity and functional groups allow for the formation of diverse chemical products.
Used in Research and Experimental Studies:
1H-Isoindol-1-one, 2,3-dihydro-4-hydroxy(9CI) is used as a research chemical to explore its properties, reactivity, and potential applications. It serves as a valuable tool for scientists to investigate new chemical reactions and mechanisms.

Upstream product

• 1290140-07-6 N-[[2-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2-methylpropane-2-amine 
• 1290140-09-8 2-tert-butyl-4-[(4-methoxyphenyl)methoxy]-3H-isoindol-1-one 
• 42981-93-1 3-methoxy-2-methylbenzoic acid methyl ester 
• 71887-28-0 methyl 2-(bromomethyl)-3-methoxybenzoate 
• 55289-06-0 3-methoxy-2-methylbenzoic acid 
• 209120-28-5 2-[(4-methoxyphenyl)methoxy]benzaldehyde 
• 1290140-08-7 O-ethyl [tert-butyl-[[2-[(4-methoxyphenyl)methoxy]phenyl]methyl]carbamoyl]sulfanylmethanethioate 
• 90-02-8 salicylaldehyde 
• 366453-22-7 4-methoxyisoindolin-1-one 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of pleuromutilin derivatives with novel C(14) side chain

In order to find novel antibacterial agents with superior antibacterial activity and overcoming multidrug resistance, a series of pleuromutilin derivatives with novel C(14) side chain were synthesized and evaluated for their in vitro antibacterial activit

PIPERIDINE DERIVATIVE

The purpose of the present invention is to provide a compound having excellent antibacterial activity against mycobacterium tuberculosis, multidrug-resistant tuberculosis bacteria, and/or non-tuberculous acid-fast bacteria. A compound represented by formula [I]: (in the formula, each symbol is as described in the attached specification), or a salt thereof can be used to diagnose, prevent, and/or treat tuberculosis.

Convenient access to isoindolinones via carbamoyl radical cyclization. Synthesis of cichorine and 4-hydroxyisoindolin-1-one natural products

An efficient and convenient access to 2-tert-butylisoindolin-1-ones via an oxidative radical cyclization process from stable carbamoylxanthates, derived from secondary tert-butylamines, is described. The proposed mechanism for this transformation involves, the generation of a carbamoyl radical, its cyclization to the aromatic system, and the dilauroyl peroxide (DLP) mediated rearomatization to generate the isoindolinone ring system. Additionally, the syntheses of cichorine and 4-hydroxyisoindolin-1-one natural products were carried out to underscore the synthetic potential of this xanthate-based carbamoyl radical-oxidative cyclization.

NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

Compounds represented by formula (1), wherein R1 is H, halogen, (C1-4)alkyl, O(C1-4)alkyl, and haloalkyl; R2 is H or methyl; R3 is H or (C1-4)alkyl; R4 is H or (C1-4)a

Non-nucleoside reverse transcriptase inhibitors

Compounds represented by formula I: wherein R1 is H, halogen, (C1-4)alkyl, O(C1-4)alkyl, and haloalkyl; R2 is H or (C1-4)alkyl; R3 is H or (C1-4)alkyl; R4 is (C1-4)alkyl, (C1-4)alkyl(C3-7)cycloalkyl, or (C3-7)cycloalkyl; and Q is a fused phenyl-5 or 6-membered saturated heterocycle having one to two heteroatoms selected from O and N, said Q being optionally substituted with hydroxy, or (C1-4)alkyl which in turn maybe optionally substituted with pyridinyl-N-oxide or C(O)OR wherein R is H or (C1-4)alkyl; or a salt thereof. The compounds have inhibitory activity against Wild Type, and single and double mutants strains, of HIV.

Inhibitors of inflammation and reperfusion injury and methods of use thereof

The invention provides a novel class of substituted isoindolinone derivatives. Pharmaceutical compositions, and methods of making and using the compounds, or pharmaceutically acceptable salts, hydrates, prodrugs, or mixtures thereof are also described.