1290140-07-6

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 75-64-9 tert-butylamine 
• 209120-28-5 2-[(4-methoxyphenyl)methoxy]benzaldehyde 
• 90-02-8 salicylaldehyde 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 1290140-08-7 O-ethyl [tert-butyl-[[2-[(4-methoxyphenyl)methoxy]phenyl]methyl]carbamoyl]sulfanylmethanethioate 
• 1290140-09-8 2-tert-butyl-4-[(4-methoxyphenyl)methoxy]-3H-isoindol-1-one 
• 366453-21-6 4-hydroxyisoindolin-1-one 

Relevant academic research and scientific papers

PIPERIDINE DERIVATIVE

The purpose of the present invention is to provide a compound having excellent antibacterial activity against mycobacterium tuberculosis, multidrug-resistant tuberculosis bacteria, and/or non-tuberculous acid-fast bacteria. A compound represented by formula [I]: (in the formula, each symbol is as described in the attached specification), or a salt thereof can be used to diagnose, prevent, and/or treat tuberculosis.

Convenient access to isoindolinones via carbamoyl radical cyclization. Synthesis of cichorine and 4-hydroxyisoindolin-1-one natural products

An efficient and convenient access to 2-tert-butylisoindolin-1-ones via an oxidative radical cyclization process from stable carbamoylxanthates, derived from secondary tert-butylamines, is described. The proposed mechanism for this transformation involves, the generation of a carbamoyl radical, its cyclization to the aromatic system, and the dilauroyl peroxide (DLP) mediated rearomatization to generate the isoindolinone ring system. Additionally, the syntheses of cichorine and 4-hydroxyisoindolin-1-one natural products were carried out to underscore the synthetic potential of this xanthate-based carbamoyl radical-oxidative cyclization.