366456-10-2

Basic information

• Product Name: N-(2-benzoyl-4-nitrophenyl)-2-(2-methylphenyl)acetamide
• Synonyms: N-(2-benzoyl-4-nitrophenyl)-2-(2-methylphenyl)acetamide
• CAS NO: 366456-10-2
• Molecular Weight: 374.396
• Mol File: 366456-10-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(2-benzoyl-4-nitrophenyl)-2-(2-methylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-benzoyl-4-nitrophenyl)-2-(2-methylphenyl)acetamide(366456-10-2)
• EPA Substance Registry System: N-(2-benzoyl-4-nitrophenyl)-2-(2-methylphenyl)acetamide(366456-10-2)

Safety Data

• Hazardous Substances Data: 366456-10-2(Hazardous Substances Data)

Upstream product

• 10166-09-3 (o-tolyl)acetyl chloride 
• 1775-95-7 2-amino-5-nitrobenzophenone 

Downstream Products

• 366456-53-3 N-[3-benzoyl-4-[2-(2-methylphenyl)acetylamino]phenyl]-N^α-tert-butyloxycarbonyl-S-tritylcysteinamide 
• 366456-40-8 N-(4-amino-2-benzoylphenyl)-2-methylphenylacetic acid amide 

Relevant articles and documents

Structure-activity relationships of novel anti-malarial agents: Part 5. N-(4-acylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides

We have developed the [5-(4-nitrophenyl)-2-furyl]acrylic acid substituted benzophenone 4g as a novel lead for anti-malarial agents. Here, we demonstrated that the acyl residue at the 2-amino group of the benzophenone core structure has to be a phenylacetic acid substructure substituted in its para-position with methyl or other substituents of similar size. The trifluoromethyl substituted derivative displayed an IC50 of 47 nM against the multi-drug resistant Plasmodium falciparum strain Dd2.

Synthesis, molecular modeling, and structure - Activity relationship of benzophenone-based CAAX-peptidomimetic farnesyltransferase inhibitors

Because of the involvement of farnesylated proteins in oncogenesis, inhibition of the protein-modifying enzyme farnesyltransferase is considered a major emerging strategy in cancer therapy. Here, we describe the structure - activity relationship of a nove