366494-36-2Relevant academic research and scientific papers
Stereocontrolled preparation of 1,2-diol with quaternary chiral center
Murata, Yoshihisa,Kamino, Tomoyuki,Hosokawa, Seijiro,Kobayashi, Susumu
, p. 8121 - 8123 (2002)
Development of an enantio- and stereoselective construction of 1,2-diols including a quaternary chiral center was achieved by a titanium-mediated aldol reaction of lactates bearing chiral oxazolidine-2-ones. anti-Aldol and syn-aldol were selectively obtained by the choice of a benzyl and TBS protecting group, respectively. Plausible transition states are also shown based on the stereochemistry of the enolate anion.
