501094-11-7Relevant academic research and scientific papers
Total synthesis of incednam, the aglycon of incednine
Ohtani, Takashi,Tsukamoto, Shinya,Kanda, Hiroshi,Misawa, Kensuke,Urakawa, Yoshifumi,Fujimaki, Takahiro,Imoto, Masaya,Takahashi, Yoshikazu,Takahashi, Daisuke,Toshima, Kazunobu
scheme or table, p. 5068 - 5071 (2010/12/25)
The first total synthesis of incednam (1), the aglycon of antibiotic incednine (2), is described. Incednine has been reported to exhibit significant inhibitory activity against the antiapoptotic oncoproteins Bcl-2 and Bcl-xL. The synthesis of 1 commenced
Stereocontrolled preparation of 1,2-diol with quaternary chiral center
Murata, Yoshihisa,Kamino, Tomoyuki,Hosokawa, Seijiro,Kobayashi, Susumu
, p. 8121 - 8123 (2007/10/03)
Development of an enantio- and stereoselective construction of 1,2-diols including a quaternary chiral center was achieved by a titanium-mediated aldol reaction of lactates bearing chiral oxazolidine-2-ones. anti-Aldol and syn-aldol were selectively obtained by the choice of a benzyl and TBS protecting group, respectively. Plausible transition states are also shown based on the stereochemistry of the enolate anion.
