366496-07-3Relevant academic research and scientific papers
Synthesis of some new unsymmetrical 1,4-dihydropyridine derivatives as potent antitubercular agents
Gaveriya, Harsukh,Desai, Bhavik,Vora, Vipul,Shah, Anamik
, p. 167 - 172 (2001)
2,6-dimethyl-3-acetyl-5-carbmethoxy-4-(3′-nitrophenyl)-1,4- dihydropyridine 1 was condensed with aromatic and heterocyclic aldehydes to form chalcone analogs 2a-h and then cyclised to substituted pyrazolines leading to novel 1,4-dihydropyridine 3a-h, 4a-h and 5a-h which are directly attached to heterocyclic moiety and devoid of the ester function at C3 (of DHP). All compounds were screened for their antitubercular activity against Mycobacterium tuberculosis (H37Rv).
