Synthesis of some new unsymmetrical 1,4-dihydropyridine derivatives as potent antitubercular agents

Article abstract of DOI:10.1515/HC.2001.7.2.167

2,6-dimethyl-3-acetyl-5-carbmethoxy-4-(3′-nitrophenyl)-1,4- dihydropyridine 1 was condensed with aromatic and heterocyclic aldehydes to form chalcone analogs 2a-h and then cyclised to substituted pyrazolines leading to novel 1,4-dihydropyridine 3a-h, 4a-h and 5a-h which are directly attached to heterocyclic moiety and devoid of the ester function at C₃ (of DHP). All compounds were screened for their antitubercular activity against Mycobacterium tuberculosis (H₃₇Rv).

Full text of DOI:10.1515/HC.2001.7.2.167

Brought to you by | Brown University Rockefeller Library (Brown University Rockefeller Library)
Authenticated | 172.16.1.226
Download Date | 6/4/12 10:39 AM

Brought to you by | Brown University Rockefeller Library (Brown University Rockefeller Library)
Authenticated | 172.16.1.226
Download Date | 6/4/12 10:39 AM

Brought to you by | Brown University Rockefeller Library (Brown University Rockefeller Library)
Authenticated | 172.16.1.226
Download Date | 6/4/12 10:39 AM

Brought to you by | Brown University Rockefeller Library (Brown University Rockefeller Library)
Authenticated | 172.16.1.226
Download Date | 6/4/12 10:39 AM

Brought to you by | Brown University Rockefeller Library (Brown University Rockefeller Library)
Authenticated | 172.16.1.226
Download Date | 6/4/12 10:39 AM

Brought to you by | Brown University Rockefeller Library (Brown University Rockefeller Library)
Authenticated | 172.16.1.226
Download Date | 6/4/12 10:39 AM