36651-18-0Relevant academic research and scientific papers
Strategies of Synthesis based on Cyclohexadienes: Part 3. A Novel Route to Macrolide Aromatic Polyketides
Birch, Arthur J.,Mani, Neelakandha S.,Rao, G. S. R. Subba
, p. 1423 - 1427 (2007/10/02)
A novel route to macrolide aromatic polyketides, having an alkyl-β-resorcylate skeleton has been developed.A formal synthesis of (+/-)-curvularin (1), and (+/-)-lasiodiplodin (3) involving the preparation of the seco acid (31) and the acyclic precursor (34) using a one pot Alder-Rickert reaction from 1,3-dimethoxycyclohexa-1,3-diene (7) and the long-chain acetylenic dienophiles (10) and (11) is reported.
