366780-93-0

Basic information

• Product Name: N_α-carbobenzyloxy-L-2-amino-4-acryloylaminobutyric acid
• Synonyms: N_α-carbobenzyloxy-L-2-amino-4-acryloylaminobutyric acid
• CAS NO: 366780-93-0
• Molecular Weight: 306.318
• Mol File: 366780-93-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N_α-carbobenzyloxy-L-2-amino-4-acryloylaminobutyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: N_α-carbobenzyloxy-L-2-amino-4-acryloylaminobutyric acid(366780-93-0)
• EPA Substance Registry System: N_α-carbobenzyloxy-L-2-amino-4-acryloylaminobutyric acid(366780-93-0)

Safety Data

• Hazardous Substances Data: 366780-93-0(Hazardous Substances Data)

Upstream product

• 2650-64-8 Cbz-L-Gln 
• 62234-40-6 (2S)-2-{[(benzyloxy)carbonyl]amino}-4-(dimethylamino)butanoic acid 
• 814-68-6 acryloyl chloride 

Downstream Products

• 366781-01-3 (N_α-carbobenzyloxy-L-2-amino-4-acryloylamino)butyrylglycine 
• 366780-97-4 (N_α-carbobenzyloxy-L-2-amino-4-acryloylamino)butyrylglycine tert-butyl ester 

Relevant articles and documents

TG2 INHIBITOR COMPOUNDS AND USES THEREOF

There are provided Tissue Transglutaminase (TG2) inhibitor compounds, and compositions and methods of use thereof for the prevention or treatment of a cancer. Compounds of Formula I, and pharmaceutically acceptable salts thereof, are provided: Formula (I).

Synthesis of dipeptide-bound epoxides and α,β-unsaturated amides as potential irreversible transglutaminase inhibitors

Herein we report the synthesis of 24 novel peptides as potential irreversible inactivators of transglutaminase (TGase). These peptides were designed to resemble Cbz-L-Gly, known to be a good TGase substrate, and to include either α,β-unsaturated amide groups or the corresponding epoxide groups. The side chain length of the amino acid residue bearing the inhibitor group was also varied in order to permit investigation of this effect. Copyright