366789-53-9

Upstream product

• 128781-07-7 5,6,7-trimethoxy-1H-indole-2-carboxylic acid 
• 366789-52-8 6-benzyloxy-3-hydroxymethyl-2,3-dihydro-1H-indole 
• 173368-77-9 6-benzyloxy-3-hydroxymethyl-N-methanesulfonyl-2,3-dihydro-1H-indole 

Downstream Products

• 351890-38-5 6-benzyloxy-3-chloromethyl-1,2-dihydro-1-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]indoline 
• 366789-59-5 [(3R/S)-3-(tert-butyldiphenylsilyl)oxymethyl-1-(5,6,7-trimethoxyindol-2'-yl-carbonyl)-2,3-dihydro-1H-indol-6-yl]-2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside 
• 366789-57-3 [(3R/S)-3-(tert-butyldiphenylsilyl)oxymethyl-1-(5,6,7-trimethoxyindol-2'-yl-carbonyl)-2,3-dihydro-1H-indol-6-yl]-2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside 
• 366789-58-4 [(3R/S)-3-(tert-butyldiphenylsilyl)oxymethyl-1-(5,6,7-trimethoxyindol-2'-yl-carbonyl)-2,3-dihydro-1H-indol-6-yl]-2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside 
• 366789-55-1 (3R/S)-3-(tert-butyldiphenylsilyl)oxymethyl-6-hydroxy-1-(5',6',7'-trimethoxyindol-2'-yl-carbonyl)-2,3-dihydro-1H-indole 

Relevant academic research and scientific papers

A strategy for tumor-selective chemotherapy by enzymatic liberation of seco-duocarmycin SA-derivatives from nontoxic prodrugs

Immuno-conjugates obtained by linking enzymes with appropriate monoclonal antibodies, which bind to tumor-associated antigens, can be employed in a tumor-selective antibody directed enzyme prodrug therapy (ADEPT). For this strategy the glycosides 17a-c we