366793-07-9

Upstream product

• 501-53-1 benzyl chloroformate 
• 366793-06-8 (4aR,19S,20S)-6-Benzyloxy-19-isopropyl-9,15-dimethyl-5,8,11,14,17,21-hexaoxo-20-(2,2,2-trichloro-ethoxycarbonylamino)-octadecahydro-18-oxa-1,6,9,12,15,21a-hexaaza-benzocyclononadecene-1-carboxylic acid benzyl ester 
• 142635-71-0 D-(N^α-Fmoc,N^δ-Cbz)-Piz-Cl 
• 366793-01-3 3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester 
• 366792-95-2 3-(benzyloxy-carboxymethyl-carbamoyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester 
• 366792-99-6 N'-{[2-(benzyloxycarbonyl-methyl-amino)-acetylamino]-acetyl}-hydrazinecarboxylic acid tert-butyl ester 
• 1026869-52-2 benzyloxyamino-acetic acid benzhydryl ester 
• 366792-96-3 N'-[(2-methylamino-acetylamino)-acetyl]-hydrazinecarboxylic acid tert-butyl ester 
• 201666-92-4 (2S,3S)-N-Troc-3-hydroxyleucine allyl ester 
• 138774-95-5 (3R)-N⁽¹⁾-Z-N⁽²⁾-Fmoc-piperazic acid 
• 366793-02-4 (2S,3S)-3-[2-(tert-Butoxycarbonyl-methyl-amino)-acetoxy]-4-methyl-2-(2,2,2-trichloro-ethoxycarbonylamino)-pentanoic acid allyl ester 
• 54837-14-8 2-(benzyloxyamino)acetic acid 
• 366793-03-5 C₄₉H₆₈Cl₃N₉O₁₆ 
• 366793-00-2 3-{benzyloxy-[({[2-(N'-tert-butoxycarbonyl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-methyl-carbamoyl)-methyl]-carbamoyl}-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester 

Relevant academic research and scientific papers

Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1)

Verucopeptin is an inhibitor of hypoxia-inducible factor 1 (HIF-1), which is a promising target for cancer chemotherapy. Here, we report the first total synthesis of verucopeptin via condensation of the depsipeptide core and the polyketide side chain unit including three branched methyl groups after the synthesis of each segment.

A synthetic strategy for the cyclodepsipeptide core of the antitumor antibiotic verucopeptin.

[reaction: see text]. An efficient [2 + 2 + 2]-fragment condensation strategy is described for obtaining the cyclodepsipeptide core of verucopeptin. The 19-membered macrocycle was established through a Carpino HATU mediated macrolactamization, which proce