54837-14-8

Basic information

• Product Name: N-(benzyloxy)glycine
• CAS NO: 54837-14-8
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.1885
• Mol File: 54837-14-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 334.4°C at 760 mmHg
• Flash Point: 156°C
• Density: 1.219g/cm³
• Vapor Pressure: 5.07E-05mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: N-(benzyloxy)glycine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(benzyloxy)glycine(54837-14-8)
• EPA Substance Registry System: N-(benzyloxy)glycine(54837-14-8)

Safety Data

• Hazardous Substances Data: 54837-14-8(Hazardous Substances Data)

Upstream product

• 66642-20-4 tert-butyl (benzyloxy)glycinate 
• 622-33-3 N-benzyloxyamine 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 41928-70-5 (E)-2-(benzyloxyimino)ethanoic acid 
• 77845-97-7 2-[(phenylmethoxy)imino]-acetic acid 
• 79-08-3 bromoacetic acid 

Downstream Products

• 73376-05-3 N-benzyloxyglycine NCA 
• 3545-78-6 N-hydroxyglycine 
• 56-40-6 glycine 
• 161146-37-8 (Benzoyl-benzyloxy-amino)-acetic acid 
• 244009-20-9 (6R,7R)-3-Acetoxymethyl-7-(2-benzyloxyamino-acetylamino)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester 
• 666861-82-1 2-benzyloxyamino-N-(2-pyridin-2-yl-ethyl)-acetamide 
• 666861-88-7 (1-{benzyloxy-[(2-pyridin-2-yl-ethylcarbamoyl)-methyl]-carbamoyl}-3-methylsulfanyl-propyl)-carbamic acid tert-butyl ester 
• 666861-89-8 (1-{benzyloxy-[(2-pyridin-2-yl-ethylcarbamoyl)-methyl]-carbamoyl}-pentyl)-carbamic acid tert-butyl ester 
• 212058-68-9 C₁₆H₁₆N₂O₄ 
• 212058-69-0 C₁₇H₁₈N₂O₄ 
• 212058-73-6 [Benzyloxy-(4-trifluoromethyl-benzoyl)-amino]-acetic acid tert-butyl ester 
• 119880-79-4 (Benzyloxy-{(S)-2-[(S)-3-(4-tert-butoxy-phenyl)-2-(5-dimethylamino-naphthalene-1-sulfonylamino)-propionylamino]-3-methyl-butyryl}-amino)-acetic acid 4-methoxy-benzyl ester 
• 86613-94-7 (Benzyloxy-formyl-amino)-acetic acid methyl ester 
• 86634-26-6 (Acetyl-benzyloxy-amino)-acetic acid methyl ester 

Relevant articles and documents

Structure-property relationship study of n-(hydroxy)peptides for the design of self-assembled parallel β-sheets

The design of novel and functional biomimetic foldamers remains a major challenge in creating mimics of native protein structures. Herein, we report the stabilization of a remarkably short β-sheet by incorporating N-(hydroxy)glycine (Hyg) residues into the backbone of peptides. These peptide- peptoid hybrids form unique parallel β-sheet structures by selfassembly upon hydrogenation. Our spectroscopic and crystallographic data suggest that the local conformational perturbations induced by N-(hydroxy)amides are outweighed by a network of strong interstrand hydrogen bonds.

Peptidyl hydroxamic acids as methionine aminopeptidase inhibitors

A new class of methionine aminopeptidase (MetAP) inhibitors, which contain an internal hydroxamate (N-acyl-N-alkylhydroxylamine) core as the metal-chelating group, has been designed, synthesized, and tested. The compounds exhibited reversible, competitive inhibition against Escherichia coli MetAP as well as human MetAP-1 and MetAP-2. The most potent inhibitor had a Ki value of 2.5 μM and >20-fold selectivity toward E. coli MAP.

Synthesis and antimicrobial properties of cephalosporin derivatives substituted on the C(7) nitrogen with arylmethyloxyimino or arylmethyloxyamino alkanoyl groups

Some 7-aminocephalosporanic acid (7-ACA) derivatives substituted on the C(7) nitrogen with 2-(arylmethyloxyimino)propionyl (3a-f), 2-(arylmethyloxyamino)propionyl (4a-d) and (arylmethyloxyamino)acetyl (2a-d) moieties were synthesized by reaction of the ap