366803-88-5Relevant academic research and scientific papers
Synthesis and biological evaluation of geminal disulfones as HIV-1 integrase inhibitors
Meadows, D. Christopher,Mathews, Timothy B.,North, Thomas W.,Hadd, Michael J.,Kuo, Chih Lin,Neamati, Nouri,Gervay-Hague, Jacquelyn
, p. 4526 - 4534 (2005)
Integration of HIV-1 viral DNA into the host genome is carried out by HIV-integrase (IN) and is a critical step in viral replication. Although several classes of compounds have been reported to inhibit IN in enzymatic assays, inhibition is not always corr
