36685-84-4

Upstream product

• 2555-49-9 phenoxyacetic acid ethyl ester 
• 98-67-9 p-hydoroxybenzenesulfonic acid 
• 105-36-2 ethyl bromoacetate 
• 825-90-1 sodium p-hydroxybenzenesulfonate 
• 863545-83-9 (4-Sulfo-phenoxy)-acetic acid ethyl ester 

Downstream Products

• 91646-00-3 (4-dimethylsulfamoyl-phenoxy)-acetic acid ethyl ester 
• 760981-56-4 ethyl {4-[2-(1H-benzimidazol-2-yl)phenylsulfamoyl]phenoxy}acetate 
• 863483-24-3 (1S,2S)-N-((4-ethoxycarbonyl)methoxybenzenesulfonyl)-1,2-diphenylethylenediamine 
• 942614-37-1 2-(4-(N-(2-(1H-benzimidazol-2-yl)-5-cyanophenyl)sulfamoyl)phenoxy)acetic acid ethyl ester 
• 942614-38-2 2-(4-(N-(5-cyano-2-(5-methoxy-1H-benzimidazol-2-yl)phenyl)sulfamoyl)phenoxy)acetic acid ethyl ester 
• 942614-39-3 (4-(2-(1H-benzimidazol-2-yl)-5-(thiazol-2-yl)phenylsulfamoyl)phenoxy)acetic acid ethyl ester 
• 942519-28-0 (4-(2-(1H-benzimidazol-2-yl)-5-methoxyphenylsulfamoyl)phenoxy)acetic acid ethyl ester 
• 942614-40-6 4-(2-formyl-4-methoxy-phenylsulfamoyl)phenoxy-acetic acid ethyl ester 
• 942614-41-7 2-(4-(N-(4-(dimethylamino)-2-formylphenyl)sulfamoyl)phenoxy)acetic acid ethyl ester 
• 1027580-09-1 C₁₈H₁₇NSO₈H₂ 
• 591775-08-5 (4-Mercapto-phenoxy)-acetic acid ethyl ester 
• 760981-60-0 ethyl {4-{2-{4-[(bispyridin-2-ylmethylamino)methyl]-1H-benzimidazol-2-yl}phenylsulfamoyl}phenoxy}acetate 
• 760981-62-2 ethyl {4-{2-{4-[(methylpyridin-2-ylmethylamino)methyl]-1H-benzimidazol-2-yl}phenylsulfamoyl}phenoxy}acetate 
• 760981-58-6 ethyl {4-{2-{4-[(diethylamino)methyl]-1H-benzimidazol-2-yl}phenylsulfamoyl}phenoxy}acetate 

Relevant academic research and scientific papers

Modulation of imine chemistry with intramolecular hydrogen bonding: Effects from ortho-OH to NH

Salicylaldehyde derivatives and their imines are important building blocks in organic and supramolecular chemistry. In an effort to expand structural diversity in the current work we changed ortho-OH in salicylaldehyde to NH of amide/sulfonamide and investigated the effect of resulting intramolecular hydrogen bonds on imine dynamic covalent chemistry (DCC). A suite of ortho-aminobenzaldehydes were readily synthesized, and X-ray and NMR data validated the existence of NH?O intramolecular hydrogen bonds. The formation and exchange of imines were then studied in acetonitrile, and the acidity of OH/NH significantly influenced the thermodynamics and kinetics of imine reactions. Furthermore, the role of OH/NH?N hydrogen bonds on imines was elucidated by the shift of aldehyde exchange equilibrium. Finally, the formation of imines was achieved in aqueous solutions. The mechanistic insights could pave the way for future applications in assembly and labelling.

BICYCLIC DERIVATIVES AS PPAR MODULATORS

The present invention is directed to compounds represented by the following structural formula, Formula (I), and stereoisomers, pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: (a) R2 is selected from the group consisting of C0-C8 alkyl and C1-4- heteroalkyl; (b) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (c) U is an aliphatic linker wherein one carbon atom of the aliphatic linker is optionally replaced with O, NH or S, and wherein such aliphatic linker is optionally substituted with from one to four substituents each independently selected from R30; (d) Y is selected from the group consisting of C, O, S, NH and a single bond; and (e) E is C(R3)(R4)A or A.

Preparation of polymer-supported Ru-TsDPEN catalysts and use for enantioselective synthesis of (S)-fluoxetine

Polymer-supported chiral ligands 9 and 17 were prepared based on Noyori's (1S,2S)- or (1R,2R)-N-(p-tolylsulfonyl)-1,2-diphenylethylenediamine. The combination with [RuCl2(p-cymene)]2 has been shown to exhibit high activities and enantioselectivities for heterogeneous asymmetric transfer hydrogenation of aromatic ketones (19a-c) with formic acid-triethylamine azeotrope as the hydrogen donor, whereby affording the respective optically active alcohols 20a-c, the key precursors of chiral fluoxetine. As exemplified by ligand 17 for substrate 19c, the catalysts can be recovered and reused in three consecutive runs with no significant decline in enantioselectivity. The procedure avoids the plausible contamination of fluoxetine by the toxic transition metal species. The Royal Society of Chemistry 2005.

Zinc(II)-selective ratiometric fluorescent sensors based on inhibition of excited-state intramolecular proton transfer

To develop a zinc(II)-selective emission ratiometric probe suitable for biological applications, we explored the cation-induced inhibition of excited-state intramolecular proton transfer (ESIPT) with a series of 2-(2′-benzene-sulfonamidophenyl)benzimidazo

FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS

The present invention is directed to compounds represented by the following structural formula, Formula I: wherein (a) X is selected from the group consisting of a single bond, O, S. S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of C, O, S, NH and a single bond; (d) E is C(R3) (R4)A or A and wherein (i) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamidek, sulfonamide and acylsulfonamide; (e) B is selected from the group consisting of S, O, C, and N; (f) Z is selected from the group consisting of N and C; with the proviso that when B is C then Z is N.

THIOPHENE DERIVATIVE PPAR MODULATORS

The present invention is directed to compounds represented by the following structural formula, Formula I: and stereoisomers, pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: (a) X is selected from the group consisting of O, S, S(O)2, N, and a bond; (b) U is an aliphatic linker wherein one carbon atom of the aliphatic linker may be replaced with O, NH or S, and wherein such aliphatic linker is optionally substituted with R30; (c) Y is selected from the group consisting of C, O, S, NH and a single bond; and (d) E is C(R3)(R4)A or A.

The solid phase synthesis of a guanidinium based 'tweezer' receptor

An appropriately functionalised guanidine has been connected to a solid support, allowing peptide chains to be attached by conventional solid phase synthesis. This provides the basis for the solid-phase synthesis of libraries of 'tweezer' receptors for peptides with a carboxylate terminus.