3669-43-0

Usage

Uses

Used in Pharmaceutical Research:
Ethanone, 1-(4-hydroxy-1-naphthalenyl)-2-phenylis used as a key intermediate in the synthesis of various pharmaceutical compounds due to its unique chemical structure and potential biological activities. Its anti-inflammatory and antioxidant properties make it a promising candidate for the development of new drugs targeting inflammation and oxidative stress-related diseases.
Used in Organic Synthesis:
In the field of organic chemistry, Ethanone, 1-(4-hydroxy-1-naphthalenyl)-2-phenylserves as a valuable building block for the synthesis of complex organic molecules. Its aromatic ketone structure allows for various chemical reactions, enabling the creation of a wide range of compounds with diverse applications.
Used in Photodynamic Therapy:
Ethanone, 1-(4-hydroxy-1-naphthalenyl)-2-phenylhas been studied for its potential as a photodynamic therapy agent for the treatment of cancer. Its ability to generate reactive oxygen species upon light activation makes it a promising candidate for targeted cancer therapy, selectively destroying cancer cells while minimizing damage to healthy tissues.
Used in Chemical Synthesis:
Ethanone, 1-(4-hydroxy-1-naphthalenyl)-2-phenylis used as a starting material in the synthesis of various chemical compounds, including dyes, pigments, and other specialty chemicals. Its unique structure and reactivity make it a versatile building block for the development of new materials with specific properties and applications.

Upstream product

• 93654-98-9 phenyl acetic acid naphthalen-1-yl ester 
• 90-15-3 α-naphthol 
• 103-82-2 phenylacetic acid 
• 103-80-0 phenylacetyl chloride 

Relevant academic research and scientific papers

Photo-Fries reaction in water made selective with a capsule

The water soluble capsule formed by a deep cavity cavitand with eight carboxylic acid groups controls product distribution during photo-Fries rearrangement of naphthyl esters in water by restricting the mobility of primary singlet radical pair. The Royal Society of Chemistry.

A convenient one-pot completely stereoselective synthesis of trans-4-Hydroxystilbenes and its derivatives and X-ray structure of its precursor

The synthesis of E-isomer of 4-Hydroxystilbene and its derivatives 3 by reductive elimination of the carbonyl function in 2-phenyl-1-(4-hydroxyphenyl)ethan-1-one and its derivatives 2 and the X-ray structure of 2a are described.

Mediation of photochemical reactions of 1-naphthyl phenylacylates by polyolefin films. A 'radical clock' to measure rates of radical-pair cage recombinations in 'viscous space'

The fates of phenylacyl/1-naphthoxy singlet radical pairs generated upon irradiation of 1-naphthyl phenylacetate (1a) and 1-naphthyl 2-phenylpropanoate (1b) in three unstretched and stretched polyethylene films and isotactic and syndiotactic polypropylene films have been investigated. From dynamic fluorescence measurements the primary locus of reactions by 1 is within amorphous regions of the films. The reaction cages afforded by these media inhibit escape of the radical pairs and mediate their reorientational motions leading to photo-Fries and related products. In essence, the cages act as stiff-walled templates. In addition, a method is described to measure the rate constants for the singlet radical pairs. Thus, the rate constants (leading to the keto precursors) of the 2-phenylacyl-1-naphthols from the radical pairs of 1 (> 108 s-1) are >6 times the rate constants for the 4-isomers. Film stretching increases this selectivity but there is no obvious correlation between the rate of the in-cage radical pair recombinations and macroscopic polymer, properties such as degree of crystallinity and frequency of branched chains. By contrast, formation of (the keto precursors of) 2-benzylic-1-naphthols (from in-cage recombinations after phenylacyl decarbonylation) is slower than for the 4-benzyl-1-naphthols. (C) 2000 Elsevier Science Ltd.