1-(4-Hydroxy-1-naphthalenyl)-2-phenylethanone

Base Information

• Chemical Name: 1-(4-Hydroxy-1-naphthalenyl)-2-phenylethanone
• CAS No.: 3669-43-0
• Molecular Formula: C18H14O2
• Molecular Weight: 262.308
• DSSTox Substance ID: DTXSID101250396
• Nikkaji Number: J1.201.239J
• Mol file: 3669-43-0.mol

Synonyms:DTXSID101250396;3669-43-0;1-(4-Hydroxy-1-naphthalenyl)-2-phenylethanone

Chemical Property of 1-(4-Hydroxy-1-naphthalenyl)-2-phenylethanone

Chemical Property:

• XLogP3: 4.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 262.099379685
• Heavy Atom Count: 20
• Complexity: 332

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(=O)C2=CC=C(C3=CC=CC=C32)O

Technology Process of 1-(4-Hydroxy-1-naphthalenyl)-2-phenylethanone

There total 9 articles about 1-(4-Hydroxy-1-naphthalenyl)-2-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

phenyl acetic acid naphthalen-1-yl ester (93654-98-9) → 1-(4-hydroxy-1-naphthyl)-2-phenylethan-1-one (3669-43-0)

Guidance literature:

With aluminium trichloride; at 60 - 70 ℃; for 1h;

DOI:10.1081/SCC-120021843

Reference yield: 46.0%

phenyl acetic acid naphthalen-1-yl ester (93654-98-9) → 1-(1-hydroxynaphthalen-2-yl)-2-phenylethanone (3669-44-1) + 1-(4-hydroxy-1-naphthyl)-2-phenylethan-1-one (3669-43-0)

Guidance literature:

With aluminium trichloride; In carbon disulfide;

DOI:10.1016/S0040-4020(00)00512-3

Reference yield:

phenylacetic acid (103-82-2) → 1-(4-hydroxy-1-naphthyl)-2-phenylethan-1-one (3669-43-0)

Guidance literature:

Multi-step reaction with 2 steps

2: 23 percent / AlCl₃ / CS₂

With aluminium trichloride; In carbon disulfide; 1: Esterification / 2: Isomerization;

DOI:10.1016/S0040-4020(00)00512-3

upstream raw materials:

phenyl acetic acid naphthalen-1-yl ester

α-naphthol

phenylacetyl chloride

phenylacetic acid