367-74-8Relevant academic research and scientific papers
N-CYANO-7-AZANORBORNANE DERIVATIVES AND USES THEREOF
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Page/Page column 81-82, (2020/03/05)
The present invention provides a compound of formula (I) or a pharmacuetically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
CHEMICAL COMPOUNDS AS ATF4 PATHWAY INHIBITORS
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Page/Page column 149-150, (2019/01/06)
The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (IIIQ): wherein X6', a, b, C8', D8', L82', L83', R81', R82', R83', R84', R85', R86', z82', z84', z85', and z86' are as defined herein; or salts thereof. The compounds of the invention are inhibitors of the ATF4 pathway. Accordingly, invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
