367-83-9

Basic information

• Product Name: 2-FLUORO-5-METHOXYBENZOIC ACID
• Synonyms: 2-FLUORO-5-METHOXYBENZOIC ACID;BUTTPARK 45\01-62;RARECHEM AL BO 0748;2-Fluoro-5-Methoxybenzoic acid, 97+%;3-Carboxy-4-fluoroanisole, 6-Fluoro-m-anisic acid;2-Fluoro-5-(methyloxy)benzoic acid;6-Fluoro-3-methoxybenzoic acid
• CAS NO: 367-83-9
• Molecular Formula: C₈H₇FO₃
• Molecular Weight: 170.14
• Product Categories: Benzoic acid;Acids & Esters;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds;Fluorine series
• Mol File: 367-83-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 146-150
• Boiling Point: 302.7 °C at 760 mmHg
• Flash Point: 136.9 °C
• Appearance: /
• Density: 1.307
• Vapor Pressure: 0.000429mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.15±0.10(Predicted)
• CAS DataBase Reference: 2-FLUORO-5-METHOXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-5-METHOXYBENZOIC ACID(367-83-9)
• EPA Substance Registry System: 2-FLUORO-5-METHOXYBENZOIC ACID(367-83-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36
• Hazardous Substances Data: 367-83-9(Hazardous Substances Data)

Usage

Chemical Properties

Class white powder

Uses

2-Fluoro-5-methoxybenzoic acid is used as an organic chemical synthesis intermediate.

InChI:InChI=1/C8H7FO3/c1-12-5-2-3-7(9)6(4-5)8(10)11/h2-4H,1H3,(H,10,11)

Upstream product

• 96826-42-5 methyl 2-fluoro-5-methoxybenzoate 
• 51446-30-1 2-fluoro-5-hydroxybenzoic acid 
• 2338-54-7 4-fluoro-3-methylanisol 
• 459-60-9 1-fluoro-4-methoxybenzene 
• 124-38-9 carbon dioxide 
• 7758-19-2 sodium chlorite 
• 5329-14-6 aminosulfonic acid 
• 105728-90-3 2-fluoro-5-methoxybenzaldehyde 
• 102-50-1 2-methyl-4-methoxyaniline 

Downstream Products

• 659737-56-1 2-fluoro-5-methoxybenzoyl chloride 
• 870221-15-1 2-fluoro-5-methoxy-4-methylbenzoic acid 
• 773134-95-5 ethyl 2-fluoro-5-methoxybenzoate 
• 91319-42-5 2-(bromomethyl)-1-fluoro-4-methoxybenzene 

Relevant articles and documents

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

Monoacylglycerol lipase (MAGL) is the enzyme degrading the endocannabinoid 2-arachidonoylglycerol, and it is involved in several physiological and pathological processes. The therapeutic potential of MAGL is linked to several diseases, including cancer. The development of MAGL inhibitors has been greatly limited by the side effects associated with the prolonged MAGL inactivation. Importantly, it could be preferable to use reversible MAGL inhibitors in vivo, but nowadays only few reversible compounds have been developed. In the present study, structural optimization of a previously developed class of MAGL inhibitors led to the identification of compound 23, which proved to be a very potent reversible MAGL inhibitor (IC50 = 80 nM), selective for MAGL over the other main components of the endocannabinoid system, endowed of a promising antiproliferative activity in a series of cancer cell lines and able to block MAGL both in cell-based as well as in vivo assays.

Palladium-catalyzed aryl-aryl cross-coupling reaction using ortho-substituted arylindium reagents

(Chemical Equation Presented) A range of biaryl compounds (aryl-aryl, aryl-heteroaryl, and heteroaryl-heteroaryl) can be efficiently prepared by a palladium-catalyzed cross-coupling reaction between ortho-substituted triarylindium reagents and aryl halide

3-(3-aryloxyphenyl)-1-(substituted methyl)-s-triazine-2,4,6-oxo or thiotrione herbicidal agents

There is provided a 3-(3-aryloxyphenyl)-1-(substituted methyl)-s-triazine-2,4,6-oxo or thiotrione compound having the structural formula I STR1 Further provided are a composition and a method comprising that compound for the control of undesirable plant s