36701-91-4

Basic information

• Product Name: 2-(2,4-dichlorophenoxy)pyridine-3-carboxylic acid
• Synonyms: 2-(2,4-dichlorophenoxy)nicotinic acid
• CAS NO: 36701-91-4
• Molecular Formula: C₁₂H₇Cl₂NO₃
• Molecular Weight: 284.0949
• Mol File: 36701-91-4.mol

Chemical Properties

• Boiling Point: 404.4°C at 760 mmHg
• Flash Point: 198.4°C
• Density: 1.497g/cm³
• Vapor Pressure: 2.88E-07mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: 2-(2,4-dichlorophenoxy)pyridine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-dichlorophenoxy)pyridine-3-carboxylic acid(36701-91-4)
• EPA Substance Registry System: 2-(2,4-dichlorophenoxy)pyridine-3-carboxylic acid(36701-91-4)

Safety Data

• Hazardous Substances Data: 36701-91-4(Hazardous Substances Data)

Upstream product

• 2942-59-8 2-chloronicotinic acid 
• 120-83-2 2,4-dichlorophenol 
• 1452-94-4 ethyl 2-chloronicotinate 

Relevant articles and documents

Design, Synthesis, and Herbicidal Activity of Novel Diphenyl Ether Derivatives Containing Fast Degrading Tetrahydrophthalimide

To seek new protoporphyrinogen oxidase (PPO) inhibitors with better biological activity, a series of novel diphenyl ether derivatives containing tetrahydrophthalimide were designed based on the principle of substructure splicing and bioisomerization. PPO inhibition experiments exhibited that 6c is the most potential compound, with the half-maximal inhibitory concentration (IC50) value of 0.00667 mg/L, showing 7 times higher activity than Oxyfluorfen (IC50 = 0.0426 mg/L) against maize PPO and similar herbicidal activities to Oxyfluorfen in weeding experiments in greenhouses and field weeding experiments. In view of the inspected bioactivities, the structure-activity relationship (SAR) of this series of compounds was also discussed. Crop selection experiments demonstrate that compound 6c is safe for soybeans, maize, rice, peanuts, and cotton at a dose of 300 g ai/ha. Accumulation analysis experiments showed that the accumulation of 6c in some crops (soybeans, peanuts, and cotton) was significantly lower than Oxyfluorfen. Current work suggests that compound 6c may be developed as a new herbicide candidate in fields.

Discovery of a new class of glucosylceramide synthase inhibitors

A novel series of potent inhibitors of glucosylceramide synthase are described. The optimization of biochemical and cellular potency as well as ADME properties led to compound 23c. Broad tissue distribution was obtained following oral administration to mice. Thus 23c could be another useful tool compound for studying the effects of GCS inhibition in vitro and in vivo.

NOVEL PHENYL AMIDE OR PYRIDYL AMIDE DERIVATIVES

This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula wherein A1, A2, B1, B2 and R1 to R11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.