36707-00-3 Usage
Uses
Used in Pharmaceutical Industry:
4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide is used as a potential therapeutic agent for the treatment of cancer. It acts as an Akt/protein kinase B inhibitor, binding to the pleckstrin homologous domain of Akt and blocking its membrane translocation. This inhibition of kinase activities leads to cell growth arrest and apoptosis, selectively targeting human cancer cells with constitutively activated Akt. 4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide's ability to disrupt critical signaling pathways in cancer cells makes it a promising candidate for further research and development in oncology.
Used in Drug Delivery Systems:
In addition to its direct therapeutic potential, 4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide may also be utilized in the development of novel drug delivery systems. These systems could enhance the compound's bioavailability, delivery, and therapeutic outcomes by employing various organic and metallic nanoparticles as carriers. This approach could help overcome limitations associated with the compound's solubility, stability, or cellular uptake, ultimately improving its efficacy against cancer cells.
Check Digit Verification of cas no
The CAS Registry Mumber 36707-00-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,7,0 and 7 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 36707-00:
(7*3)+(6*6)+(5*7)+(4*0)+(3*7)+(2*0)+(1*0)=113
113 % 10 = 3
So 36707-00-3 is a valid CAS Registry Number.
InChI:InChI=1/C13H15N5O6/c14-10-6-7(20)4(11(15)23)1-18(12(6)17-3-16-10)13-9(22)8(21)5(2-19)24-13/h1,3,5,8-9,13,19,21-22H,2H2,(H2,15,23)(H2,14,16,17)
36707-00-3Relevant academic research and scientific papers
COMPOUNDS USEFUL AS AKT/PKB MODULATORS AND USES THEREOF
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Page/Page column 107, (2012/12/13)
Compounds, and pharmaceutical compositions, and formulations thereof, are disclosed that have formula (I): where R1a, R1b, R1c, R2, R3, R6a, R6b, R6c, R7, and R8 are as defined herein. The compounds, pharmaceutical compositions, and pharmaceutical formulations thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others. The manufacturing and analytical methods for LD- 101 are also disclosed.
