36707-42-3Relevant academic research and scientific papers
Design, synthesis and biological evaluation of potent NAD +-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-Amino-pyrido[2,3-d]pyrimidin-5(8H)-ones
Wang, Tiansheng,Duncan, Leonard,Gu, Wenxin,O'Dowd, Hardwin,Wei, Yunyi,Perola, Emanuele,Parsons, Jonathan,Gross, Christian H.,Moody, Cameron Stuver,Ryan Arends,Charifson, Paul S.
, p. 3699 - 3703 (2012)
A series of 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones were designed and synthesized as a novel class of inhibitors of NAD+-dependent DNA ligase that possess potency against Gram-positive bacteria.
COMPOUNDS USEFUL AS AKT/PKB MODULATORS AND USES THEREOF
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Page/Page column 104-105, (2012/12/13)
Compounds, and pharmaceutical compositions, and formulations thereof, are disclosed that have formula (I): where R1a, R1b, R1c, R2, R3, R6a, R6b, R6c, R7, and R8 are as defined herein. The compounds, pharmaceutical compositions, and pharmaceutical formulations thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others. The manufacturing and analytical methods for LD- 101 are also disclosed.
Antibacterial compounds
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Page/Page column 20, (2010/02/12)
Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.
