36707-42-3

Basic information

• Product Name: diethyl ({[6-amino-2-(methylsulfanyl)pyrimidin-4-yl]amino}methylidene)propanedioate
• CAS NO: 36707-42-3
• Molecular Formula: C₁₃H₁₈N₄O₄S
• Molecular Weight: 326.3714
• Mol File: 36707-42-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 470.5°C at 760 mmHg
• Flash Point: 238.3°C
• Density: 1.31g/cm³
• Vapor Pressure: 5.05E-09mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: diethyl ({[6-amino-2-(methylsulfanyl)pyrimidin-4-yl]amino}methylidene)propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl ({[6-amino-2-(methylsulfanyl)pyrimidin-4-yl]amino}methylidene)propanedioate(36707-42-3)
• EPA Substance Registry System: diethyl ({[6-amino-2-(methylsulfanyl)pyrimidin-4-yl]amino}methylidene)propanedioate(36707-42-3)

Safety Data

• Hazardous Substances Data: 36707-42-3(Hazardous Substances Data)

Upstream product

• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 1005-39-6 4,6-diamino-2-methylthiopyrimidine 
• 41343-58-2 diethyl 2-ethoxymaleate 

Downstream Products

• 36707-00-3 4-amino-5,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide 
• 36707-44-5 4-acetylamino-2-methylsulfanyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester 
• 36707-43-4 [(6-acetylamino-2-methylsulfanyl-pyrimidin-4-ylamino)-methylene]-malonic acid diethyl ester 

Relevant articles and documents

Design, synthesis and biological evaluation of potent NAD +-dependent DNA ligase inhibitors as potential antibacterial agents. Part 2: 4-Amino-pyrido[2,3-d]pyrimidin-5(8H)-ones

A series of 4-amino-pyrido[2,3-d]pyrimidin-5(8H)-ones were designed and synthesized as a novel class of inhibitors of NAD+-dependent DNA ligase that possess potency against Gram-positive bacteria.

Antibacterial compounds

Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.