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3-(1-Ethyl-3-pyrrolidinyl)-1H-indole is a chemical compound with the molecular formula C14H18N2. It is a derivative of indole, a heterocyclic aromatic organic compound that is a core structure of the amino acid tryptophan. The compound features a pyrrolidine ring fused to the indole structure, with an ethyl group attached to the nitrogen atom of the pyrrolidine. This specific arrangement of atoms and functional groups gives the compound unique chemical and physical properties, which may be relevant in various applications, such as pharmaceuticals or materials science. The compound's structure and properties make it a potential candidate for further study in the development of new drugs or as a building block in the synthesis of more complex molecules.

3671-01-0

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3671-01-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3671-01-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,6,7 and 1 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 3671-01:
(6*3)+(5*6)+(4*7)+(3*1)+(2*0)+(1*1)=80
80 % 10 = 0
So 3671-01-0 is a valid CAS Registry Number.
InChI:InChI=1/C14H18N2/c1-2-16-8-7-11(10-16)13-9-15-14-6-4-3-5-12(13)14/h3-6,9,11,15H,2,7-8,10H2,1H3

3671-01-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(1-ethylpyrrolidin-3-yl)-1H-indole

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:3671-01-0 SDS

3671-01-0Relevant academic research and scientific papers

Synthesis and structure activity relationship of rigidized indolyl pyrrolidine derivatives as 5-HT6 receptor ligands

Nirogi, Ramakrishna,Dwarampudi, Adireddy,Bhatta, Venugopalarao,Kota, Laxman,Dubey

, p. 9293 - 9298 (2013/11/19)

A novel series of rigidized indolyl pyrrolidine derivatives have been designed by constraining the tryptamine nitrogen through a and b carbons. All the synthesized derivatives have shown moderate affinities at 5-HT6R when tested in in vitro binding assay.

Rigidized 1-aryl sulfonyl tryptamines: Synthesis and pharmacological evaluation as 5-HT6 receptor ligands

Nirogi, Ramakrishna,Dwarampudi, Adireddy,Kambhampati, Ramasastry,Bhatta, Venugopalarao,Kota, Laxman,Shinde, Anil,Badange, Rajesh,Jayarajan, Pradeep,Bhyrapuneni, Gopinadh,Dubey

, p. 4577 - 4580 (2011/09/12)

A series of N1-arylsulfonyl-3-(pyrrolidin-3-yl)-1H-indole and N1-arylsulfonyl-3-(4-chloro-2,5-dihydro-1H-pyrrol-3-yl)-1H-indole derivatives (tryptamine derivatives with rigidized side chain) have been prepared and tested for their binding affinity to 5-HT6 receptor. Several compounds displayed potent binding affinity for the 5-HT6 receptor when tested in in vitro binding assay. The primary SAR indicates that rigidification of dimethylamino alkyl chain at C3 of indole carbon maintains the binding affinity to 5-HT6R. The lead compound N 1-benzenesulfonyl-3-(4-chloro-1-methyl-2,5-dihydro-1H-pyrrol-3-yl) -1H-indole, 10a (Kb = 0.1 nM) has shown excellent in vitro affinity and was active in animal models of cognition like NORT and water maze.

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