367255-31-0Relevant academic research and scientific papers
Substituted indole-5-carboxamides and -acetamides as potent nonpeptide GnRH receptor antagonists
Ashton, Wallace T.,Sisco, Rosemary M.,Yang, Yi Tien,Lo, Jane-Ling,Yudkovitz, Joel B.,Cheng, Kang,Goulet, Mark T.
, p. 1723 - 1726 (2001)
The 2-aryltryptamine class of GnRH receptor antagonists has been modified to incorporate carboxamide and acetamide substituents at the indole 5-position. With either a phenol or methanesulfonamide terminus on the N-aralkyl side chain, potent binding affin
Pyrazol-1-ylphenylacetic acids
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, (2008/06/13)
Pyrazol-1-ylphenylacetic acids of the formula STR1 wherein R1, R2 and R3 are the same or different and denote a hydrogen atom or a halogen atom, R4 denotes a hydrogen atom or an alkyl group, A B denotes a carbon-carbon single or double bond, and their salts are pharmacologically active and are useful as medicaments. Medicament compositions are produced therefrom. Their functional carboxylic acid derivatives and other new intermediates are used in their preparation.
