367263-52-3

Upstream product

• 112-72-1 1-Tetradecanol 
• 367263-49-8 5-benzyloxymethyl-5-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2-carboxylic acid 
• 367263-47-6 5-[(Benzyloxy)methyl]-5-[(4-methoxyphenoxy)methyl]tetrahydro-2-furancarbonitrile 
• 367263-43-2 5-[(Benzyloxy)methyl]-5-[(4-metoxyphenoxy)methyl]tetrahydro-2-furanol 
• 367263-45-4 2-benzyloxymethyl-5-chloro-2-(4-methoxy-benzyloxymethyl)-tetrahydro-furan 
• 100-51-6 benzyl alcohol 
• 213122-44-2 1-benzyloxy-3-(4-methoxybenzyloxy)propan-2-one 
• 213122-45-3 1-(Benzyloxy)-2-[(4-metoxyphenoxy)methyl]-4-hexen-2-ol 
• 162427-33-0 1-benzyloxy-3-(p-methoxybenzyloxy)propan-2-ol 
• 108836-41-5 2-((4-methoxybenzyloxy)methyl)oxirane 

Relevant academic research and scientific papers

5-Acyloxy-5-hydroxymethyltetrahydro-2-furancarboxylate as a novel template for protein kinase C (PKC) binding

A series of alkyl tetrahydrofuran-2-carboxylates (1-4) bearing a new set of three pharmacophoric groups were tested as protein kinase C (PKC) ligands. The compounds were synthesized from commercially available glycidyl 4-methoxyphenyl ether. The correlation between their binding affinities for PKC-α and a conformational fit to phorbol ester indicates they mimic a pharmacophore model comprising the C20-OH, C3-C=O and C9-OH rather than that including the C13-C=O moiety.