36728-58-2

Upstream product

• 504-24-5 4-aminopyridine 
• 2235-01-0 dimethoxydiphenylmethane 
• 1013-88-3 Benzophenone imine 
• 7379-35-3 4-chlorpyridine hydrochloride 
• 36316-71-9 2-chloropyridine hydrochloride 
• 119-61-9 benzophenone 

Relevant academic research and scientific papers

Dynamic control of dendrimer-fullerene association by axial coordination to the core

The effect of axial coordination of pyridine derivatives to the core porphyrin on the fullerene encapsulation of the 4th generation carbazole-phenylazomethine dendrimer (ZnPG2-2) was investigated. The axial coordination of large (bulky) pyridine derivativ

Highly reactive, general, and long-lived catalysts for coupling heteroaryl and aryl chlorides with primary nitrogen nucleophiles

Resisting pathways for decomposition followed by palladium complexes of monodentate ligands is one characteristic of the highly reactive but long-lived catalyst generated from the Josiphos ligand L and palladium. It catalyzes under mild conditions the coupling of primary amines with chloropyridines and chloroarenes in high yield with low catalyst loadings (see scheme).

Amination reactions of aryl halides with nitrogen-containing reagents mediated by palladium/imidazolium salt systems

Nucleophilic N-heterocyclic carbenes have been conveniently used as catalyst modifiers in amination reactions involving aryl chlorides, aryl bromides, and aryl iodides with various nitrogen-containing substrates. The scope of a coupling process using a Pd(0) or Pd(II) source and an imidazolium salt in the presence of a base, KOtBu or NaOH, was tested using various substrates. The Pd2(dba)3/IPr·HCl (1, IPr = 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) system presents the highest activity with respect to electron-neutral and electron-rich aryl chlorides. The ligand is also effective for the synthesis of benzophenone imines, which can be easily converted to the corresponding primary amines by acid hydrolysis. Less reactive indoles were converted to N-aryl-substituted indoles using as supporting ligand the more donating SIPr·HCl (5, SIPr = 1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene). The Pd(OAc)2/SIPr·HCl/NaOH system is efficient for the N-arylation of diverse indoles with aryl bromides. The general protocol developed has been applied successfully to the synthesis of a key intermediate in the synthesis of an important new antibiotic. Mechanistically, palladium-to-ligand ratio studies strongly support an active species bearing one nucleophilic carbene ligand.

Lanthanide triflate catalysed reactions of acetals with primary amines and cascade cyclisation reactions

The formation of imines from acetals and primary amines can be carried out at significantly lower temperatures using scandium or lanthanide triflates as catalysts, than in the absence of a catalyst: the intermediate aminol ethers can also take part in cascade cyclisation reactions, for example using tryptamine and ethyl tryptophanate.

Study of the Azide Ion Reactivity Towards Heterocyclic Cations. V. Syntheses, Thermal and Photochemical Rearrangements of α,α'-Diphenylpyridylazidomethanes

The syntheses of α,α'-diphenylpyridylazidomethanes are reported and the thermal and photochemical rearrangements of these azides are studied.For the thermolysis and photolysis of these azides a step by step mechanism is proposed.The differences between th