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36735-22-5

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36735-22-5 Usage

Description

Quazepam is a rapidly acting, short term hypnotic reported to exhibit a low incidence of side effects.

Originator

Schering (USA)

Uses

Quazepam is a benzodiazepine derivative drug and is known to bind nonspecifically to benzodiazepine receptors, which affects muscle relaxation, anticonvulsant activty, motor coordination and memory. Quazepam is known to induce motor impairment and exerts hypnotic properties. Quazepam is often used for the treatment of insomina.

Brand name

Doral (Questcor).

General Description

Quazepam (Doral) and its active metabolitesreportedly are relatively selective for the benzodiazepinemodulatory site on GABAA receptors with α1 subunitand are hypnotic agents. Quazepam is metabolized by oxidation to the 2-oxo compound and then N-dealkylation.Both metabolites are active; the first reportedly is the morepotent and selective. Thereafter, 3-hydroxylation and glucuronidationoccur.

Check Digit Verification of cas no

The CAS Registry Mumber 36735-22-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,7,3 and 5 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 36735-22:
(7*3)+(6*6)+(5*7)+(4*3)+(3*5)+(2*2)+(1*2)=125
125 % 10 = 5
So 36735-22-5 is a valid CAS Registry Number.
InChI:InChI=1/C17H11ClF4N2S/c18-10-5-6-14-12(7-10)16(11-3-1-2-4-13(11)19)23-8-15(25)24(14)9-17(20,21)22/h1-7H,8-9H2

36735-22-5 Well-known Company Product Price

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  • USP

  • (1592205)  Quazepam  United States Pharmacopeia (USP) Reference Standard

  • 36735-22-5

  • 1592205-200MG

  • 5,736.51CNY

  • Detail

36735-22-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-chloro-5-(2-fluorophenyl)-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepine-2-thione

1.2 Other means of identification

Product number -
Other names Oniria

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:36735-22-5 SDS

36735-22-5Synthetic route

quazepam
36735-22-5

quazepam

[3H]-2-Oxoquazepam
49606-44-2

[3H]-2-Oxoquazepam

Conditions
ConditionsYield
With Hg(CH3COO)2 at 20℃; for 0.25h; pH 11.2 (Britton-Robinson buffer); 40percent DMF as solubilisator;100%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 10℃;50%
mercaptoacetic acid
68-11-1

mercaptoacetic acid

quazepam
36735-22-5

quazepam

10-chloro-7,11b-dihydro-11b-(2-fluorophenyl)-7-(2,2,2-trifluoro-ethyl)-thiazolo<3,2-d><1,4>benzodiazepin-3(2H)one-6(5H)thione

10-chloro-7,11b-dihydro-11b-(2-fluorophenyl)-7-(2,2,2-trifluoro-ethyl)-thiazolo<3,2-d><1,4>benzodiazepin-3(2H)one-6(5H)thione

Conditions
ConditionsYield
In benzene for 45h; Heating;42%

36735-22-5Upstream product

36735-22-5Downstream Products

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