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| CAS No.: | 36735-22-5 |
|---|---|
| Name: | QUAZEPAM CIV (200 MG) |
| Molecular Structure: | |
|
|
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| Formula: | C17H11 Cl F4 N2 S |
| Molecular Weight: | 386.8 |
| Synonyms: | 7-Chloro-1-(2,2,2-trifluoroethyl)-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepine-2-thione;7-Chloro-1-(2,2,2-trifluoroethyl)-1,3-dihydro-5-(o-fluorophenyl)-2H-1,4-benzodiazepine-2-thione;Doral; Dormalin; NSC 309702; Oniria; Prosedar; Quazepam; Quazium; Sch 16134;Selepam |
| EINECS: | 253-179-4 |
| Density: | 1.42 g/cm3 |
| Melting Point: | 22°C |
| Boiling Point: | 429.9 °C at 760 mmHg |
| Flash Point: | 213.8 °C |
| PSA: | 47.69000 |
| LogP: | 4.52680 |
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quazepam
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[3H]-2-Oxoquazepam
| Conditions | Yield |
|---|---|
| With Hg(CH3COO)2 at 20℃; for 0.25h; pH 11.2 (Britton-Robinson buffer); 40percent DMF as solubilisator; | 100% |
| With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 10℃; | 50% |
- 68-11-1
mercaptoacetic acid
- 36735-22-5
quazepam
| Conditions | Yield |
|---|---|
| In benzene for 45h; Heating; | 42% |
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Chemistry
IUPAC Name: 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-
The MF of 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5) is C9H6N2S.
The MW of 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5) is 174.22234.
Synonyms of 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5): 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- ; 7-Chloro-5-(o-fluorophenyl)-1,3-dihydro-1-(2,2, 2-trifluoroethyl)-2H-1,4-benzodiazepine-2-thione
Apperance: dichloromethane - hexane crystallization
Index of Refraction: 1.595
EINECS: 253-179-4
Density: 1.42 g/ml
Flash Point: 213.8 °C
Boiling Point: 429.9 °C
Melting Point: 137.5-139 °C
Uses
2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5) is benzodiazepine class with a typical anti-anxiety, anti-seizure and muscle relaxant effect and low toxicity. Used for a variety of insomnia.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LD | oral | > 1gm/kg (1000mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: ANALGESIA | Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 1456, 1982. |
| dog | LD | oral | > 1gm/kg (1000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987. | |
| mouse | LD50 | intraperitoneal | 845mg/kg (845mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987. |
| mouse | LDLo | oral | 5gm/kg (5000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 1456, 1982. | |
| rat | LD50 | intraperitoneal | 2749mg/kg (2749mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987. |
| rat | LD50 | oral | > 5gm/kg (5000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987. |
Safety Profile
Safety information of 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5):
RIDADR 3249
HazardClass 6.1(b)
PackingGroup III