36747-64-5

Usage

Uses

Used in Pharmaceutical Industry:
4-(DICHLOROMETHYL)BENZOYL CHLORIDE 95 is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs with improved therapeutic properties and reduced side effects.
Used in Agrochemical Industry:
In the agrochemical industry, 4-(DICHLOROMETHYL)BENZOYL CHLORIDE 95 is utilized as a precursor for the production of various agrochemicals, including pesticides and herbicides. Its reactivity enables the creation of effective and targeted chemical solutions for agricultural applications.
Used in Specialty Chemicals Industry:
4-(DICHLOROMETHYL)BENZOYL CHLORIDE 95 is employed as a versatile building block in the synthesis of specialty chemicals, such as benzoyl derivatives and chlorinated compounds. Its unique properties contribute to the development of innovative and high-performance chemical products for various applications.
Used in Research and Development:
This chemical compound is also used in research and development settings, where it serves as a valuable tool for exploring new chemical reactions and synthesizing novel organic compounds. Its reactivity and versatility make it an essential component in the advancement of scientific knowledge and the development of new technologies.

Upstream product

• 874-60-2 4-methyl-benzoyl chloride 
• 619-66-9 4-Carboxybenzaldehyde 
• 10026-13-8 phosphorus pentachloride 
• 623-24-5 1,4-bis(bromomethyl)benzene 
• 99-94-5 p-Toluic acid 

Downstream Products

• 99846-96-5 methyl 4-α,α-dichloromethylbenzoate 
• 4034-23-5 4-dichloromethyl-benzoic acid-[(1RS,2RS)-2-hydroxy-1-hydroxymethyl-2-(4-nitro-phenyl)-ethylamide] 
• 5278-91-1 4-dichloromethyl-benzoic acid 
• 619-66-9 4-Carboxybenzaldehyde 
• 4264-41-9 6β-(4-dichloromethyl-benzoylamino)-penicillanic acid 
• 47765-77-5 6β-[(Ξ)-2-(4-dichloromethyl-benzoylamino)-2-phenyl-acetylamino]-penicillanic acid 

Relevant academic research and scientific papers

BIVALENT LECA INHIBITORS TARGETING BIOFILM FORMATION OF PSEUDOMONAS AERUGINOSA

The present invention relates to divalent compounds binding to LecA. The compounds are useful to block biofilm formation of Pseudomonas aeruginosa. The invention further relates to pharmaceutical compositions comprising these compounds and to therapeutic methods and uses of these compounds, in particular to therapeutic methods and uses for the treatment of Pseudomonas aeruginosa infections in a subject. The invention also relates to imaging of infections, such as biofilms produced by Pseudomonas aeruginosa, by using these divalent compounds.

Scale-up of the synthesis of a pyrimidine derivative directly on solid support

The solid-phase synthesis of 4-(2-amino-6-phenylpyrimidin-4-yl)benzamide, a compound obtained through combinatorial chemistry and parallel synthesis, can be scaled up directly on solid support in excellent yields and high purity. By applying highly loaded aminomethyl polystyrene as solid support, a good ratio between the product and the starting resin is achieved. For comparison, the synthesis was also performed in solution. The solid-phase synthesis approach has the advantage that the desired compound is easily and quickly accessible in sufficient quantities for early development demands.

SOLUBILITY OF CHLORINE AND HYDROGEN CHLORIDE IN p-TOLUOYL CHLORIDE AND IN THE PRODUCTS OF ITS CHLORINATION IN THE SIDE CHAIN.

In view of the absence of literature data on solubilities of chlorine and hydrogen chloride in the system under consideration and the need to have such data for determination of the kinetic parameters of the chlorination reaction, the authors studied the solubility of chlorine and hydrogen chloride in p-toluoyl chloride and in the products of its chlorination in the side chain (chloro-, dichloro-, and trichloromethylbenzoyl chlorides). The results of this investigation show that the solubilities of chlorine and hydrogen chloride in acyl chlorides depend appreciably on temperature and less on the nature of the compounds. Determination of the dependence of solubility of chlorine in p-toluoyl chloride at 40 degree on the partial pressure of chlorine in the gas phase gave a linear relationship, indicating that the system obeys Henry's law.