36748-28-4

Upstream product

• 90-02-8 salicylaldehyde 
• 26945-93-7 2-tert-butyliminomethylphenol 
• 142-71-2 copper diacetate 
• 75-64-9 tert-butylamine 

Downstream Products

• 26194-23-0 {Cu(C₆H₄(O)CHNCH₂CH₃)2} 
• 14096-19-6 bis(N-ethylsalicylaldiminato)copper(II) 
• 14077-14-6 bis(N-i-propylsalicylaldiminato)copper(II) 

Relevant academic research and scientific papers

Synthesis of Carba-Cyclophellitols: a New Class of Carbohydrate Mimetics

Cyclophellitol and cyclophellitol aziridine are potent and irreversible inhibitors of retaining β-glucosidases. They preferentially adopt a 4H3 half-chair conformation, thereby mimicking the substrate-transition-state conformation characteristic of retaining β-glucosidases. As a consequence, both compounds bind tightly to the enzyme active site, and attack of the catalytic nucleophile onto the epoxide/aziridine results in enzyme deactivation. Replacement of the epoxide oxygen in cyclophellitol by a (substituted) carbon yielded carba-cyclophellitols, a conceptually new class of inhibitors of retaining β-glucosidases, as we demonstrated in a recent communication. In this paper, in-depth synthetic studies of this class of compounds are described, and the preparation of a comprehensive set of structurally and configurationally new carba-cyclophellitols is presented.

Cobalt(II), copper(II), zinc(II) and palladium(II) Schiff base complexes: Synthesis, characterization and catalytic performance in selective oxidation of sulfides using hydrogen peroxide under solvent-free conditions

An asymmetric bidentate Schiff-base ligand (HL: 2-tert-butyliminomethyl-phenol) was prepared from the reaction of salicylaldehyde and tert-butylamine. Cobalt(II), copper(II), zinc(II) and Pd(II) complexes, CoL2, CuL2, ZnL2 and PdL2, were synthesized from the reaction of CoCl2·6H2O, CuCl2·2H2O, Zn(NO3)2·6H2O and PdCl2 with the bidentate Schiff base ligand HL in methanol. The ligand and its metal complexes were characterized by elemental analysis (CHN), FT-IR and UV-Vis spectroscopy. In addition, 1H and 13C NMR techniques were employed for characterization of the ligand (HL) and the diamagnetic complexes (ZnL2 and PdL2). The molecular structures of all the complexes were determined by the single crystal X-ray diffraction technique. The crystallographic data reveal that in all the complexes the metal centers are four-coordinated by two phenolate oxygen and two imine nitrogen atoms of two Schiff base ligands. The geometry around the metal center in the CoL2, CuL2 and ZnL2 complexes is a distorted tetrahedral and for PdL2 it is square-planar. The catalytic activity of these complexes has been evaluated for the selective oxidation of sulfides with the green oxidant 35% aqueous H2O2 under solvent free conditions. For all the catalysts, using optimized reaction conditions, different sulfides were converted to the corresponding sulfones. ZnL2 showed a higher catalytic performance for the oxidation of the different sulfides to the corresponding sulfones.