36748-79-5Relevant academic research and scientific papers
Palladium-Catalyzed Modular Synthesis of Substituted Piperazines and Related Nitrogen Heterocycles
Montgomery, Thomas D.,Rawal, Viresh H.
, p. 740 - 743 (2016)
We report here a novel method for the modular synthesis of highly substituted piperazines and related bis-nitrogen heterocycles via a palladium-catalyzed cyclization reaction. The process couples two of the carbons of a propargyl unit with various diamine components to provide nitrogen heterocycles in generally good to excellent yields and high regio- and stereochemical control. (Chemical Equation Presented).
Palladium-Catalyzed [4+2] and [5+2] Annulation for the Synthesis of Tetrahydroquinolines and 1,4-Benzoxazepines
Zhang, Zhao-Fei,Zhang, Yan,Zhang, Chun-Lin,Ye, Song
, p. 3059 - 3062 (2020)
Palladium-catalyzed [4+2] and [5+2] annulations of propargyl carbonates with malonate-tethered anilines and 2-aminobenzylic alcohols were developed, giving the corresponding tetrahydroquinolines and 1,4-benzoxazepines, respectively, in good to excellent yields.
