36750-84-2Relevant academic research and scientific papers
N-alkylation of 2,4,5-triphenyl imidazole derivatives using a new phase transfer reagent under PTC conditions
Jayachandran,Wang
, p. 2743 - 2752 (2001)
The phase transfer catalyzed N-alkylation of 2,4,5-triphenyl imidazole derivatives using a new phase transfer reagent namely, 2-benzilidine-N,N,N,N′,N′,N′-hexaethyl propane-1,3-diammonium dibromide have been described. The structures of all the 14 compounds have been established by spectroscopic means.
Ag–TiO2 nanocomposite-catalyzed one-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles: a green and benign approach
Alipour, Soghra,Vahdat, Seyed Mohammad,Chekin, Fereshteh
, p. 2315 - 2321 (2021/05/27)
Ag–TiO2 nanocomposite as an efficient catalyst was synthesized and characterized by AFM analysis. This nanocomposite acts as a heterogeneous and recyclable catalyst for the room temperature synthesis of 1,2,4,5-tetrasubstituted imidazoles from aldehydes, benzil, ammonium acetate and several anilines or aliphatic amines via one-pot four-component condensation reaction in H2O as a green solvent. Ag–TiO2 nanocomposite was simply recovered by filtration and was reused up to three times.
A facile multicomponent synthesis of tetrasubstituted imidazoles using Fe3+-K10 catalyst under solvent-free microwave conditions
Raghuvanshi,Singh, Krishna Nand
experimental part, p. 1394 - 1397 (2011/01/13)
An efficient, microwave assisted, multi-component synthesis of 1,2,4,5-tetrasubstituted imidazoles has been achieved by the one-pot condensation of benzil, aromatic aldehyde, aliphatic/aromatic amine and ammonium acetate using Fe3+-K10 heterogeneous catalyst under solvent-free conditions. This approach offers a number of advantages such as excellent yield, solvent-free conditions, short reaction time, an eco-friendly and low loading catalyst, mild reaction temperature, and an easy work-up.
An efficient and one-pot synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles catalyzed by InCl3·3H2O
Das Sharma, Saikat,Hazarika, Parasa,Konwar, Dilip
, p. 2216 - 2220 (2008/09/18)
InCl3·3H2O was found to be a mild and effective catalyst for the efficient, one-pot, three component synthesis of 2,4,5-trisubstituted imidazoles at room temperature. Moreover, the utility of this protocol was further explored conveniently for the one-pot, four component synthesis of 1,2,4,5-tetrasubstituted imidazoles in high yields.
Preparation and antiinflammatory activity of some nonacidic trisubstituted imidazoles
Lombardino,Wiseman
, p. 1182 - 1188 (2007/10/04)
A number of trisubstituted imidazoles were made and several found to be potent antiinflammatory agents when examined in the carrageenan rat paw edema test. The antiinflammatory activity of these compounds is retained in adrenalectomized rats. Unlike many previously reported antiinflammatory agents, these compounds are extremely weak acids pK[a] ≥ 11) and are therefore not ionized at physiological pH. One compound, 4,5 bis (4 methoxyphenyl) 2 trifluoromethylimidazole (flumizole), is more potent than indometacin in the rat paw edema test and, in contrast to some related compounds, does not cause photosensitization in mice.
