367511-37-3Relevant academic research and scientific papers
Synthesis of a novel cyclopropyl phosphonate nucleotide as a phosphate mimic
Altenhofer, Erich F.,Fowler-Watters, Matthew,Joyce, Leo A.,Kumar, Pankaj,Lawler, Michael J.,Li, Zhen,Pei, Tao
supporting information, p. 6808 - 6811 (2021/07/13)
The inherentin vivoinstability of oligonucleotides presents one of many challenges in the development of RNAi-based therapeutics. Chemical modification to the 5′-terminus serves as an existing paradigm which can make phosphorylated antisense strands less prone to degradation by endogenous enzymes. It has been recently shown that installation of 5′-cyclopropyl phosphonate on the terminus of an oligonucleotide results in greater knockdown of a targeted protein when compared to its unmodified phosphate derivative. In this paper we report the synthesis of a 5′-modified uridine.
S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS
-
Paragraph 0068; 0474, (2021/06/22)
Various embodiments provide STOPS? polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS? modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS? modified oligonucleotides, as determined by HBsAg Secretion Assay, is an EC50 that is less than 100 nM.
ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF
-
Page/Page column 623, (2016/06/15)
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF
-
Page/Page column 631, (2016/06/28)
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
Alternative nucleic acid molecules and uses thereof
-
Paragraph 2174; 2175, (2015/11/09)
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF
-
Page/Page column 290, (2014/07/07)
The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.
Can Phosphate-Branched RNA Persist under Physiological Conditions?
L?nnberg, Tuomas A.
, p. 2690 - 2700 (2013/02/26)
A 2′-O-methyl-RNA oligonucleotide containing a single free 2′-OH group flanking a branching phosphotriester linkage was prepared as a model for phosphate-branched RNA by using an orthogonally protected dimeric phosphoramidite building block in solid-phase
