367511-37-3

Basic information

• Product Name: C₂₂H₄₂N₂O₆Si₂
• CAS NO: 367511-37-3
• Molecular Weight: 486.756
• Mol File: 367511-37-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: C₂₂H₄₂N₂O₆Si₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₄₂N₂O₆Si₂(367511-37-3)
• EPA Substance Registry System: C₂₂H₄₂N₂O₆Si₂(367511-37-3)

Safety Data

• Hazardous Substances Data: 367511-37-3(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 2140-76-3 2'-O-methyluridine 

Downstream Products

• 171268-84-1 1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 
• 13048-95-8 N4,2'-O-dimethylcytidine 
• 1613530-40-7 C₂₃H₄₅N₃O₅Si₂ 
• 1428902-86-6 C₂₄H₄₃N₅O₅Si₂ 

Relevant articles and documents

Synthesis of a novel cyclopropyl phosphonate nucleotide as a phosphate mimic

The inherentin vivoinstability of oligonucleotides presents one of many challenges in the development of RNAi-based therapeutics. Chemical modification to the 5′-terminus serves as an existing paradigm which can make phosphorylated antisense strands less prone to degradation by endogenous enzymes. It has been recently shown that installation of 5′-cyclopropyl phosphonate on the terminus of an oligonucleotide results in greater knockdown of a targeted protein when compared to its unmodified phosphate derivative. In this paper we report the synthesis of a 5′-modified uridine.

ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.

Alternative nucleic acid molecules and uses thereof

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.